Consortium Members

Australian Phenomics Network Canadian Institutes of Health Research Genome Canada The Centre for Phenogenomics CAM-SU Genomic Resource Center, Soochow University MARC Nanjing University Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College Medical Research Council, Harwell Wellcome Trust Sanger Institute / European Bioinformatics Institute Helmholtz-Zentrum Muenchen PHENOMIN CNR Monterotondo Czech Centre for Phenogenomics, IMG Universitat Autònoma de Barcelona Indian Institutes of Science Education and Research, Pune RIKEN BioResource Research Center The Jackson Laboratory UC Davis National Institutes of Health (NIH) Children’s Hospital Oakland Research Institute Charles River Laboratories Baylor College of Medicine PCDDP North-West University Korea Mouse Phenotype Consortium NLAC

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Australia

Australian Phenomics Network

Phenomics Australia, formerly the Australian Phenomics Network (APN), is a forward-thinking research infrastructure provider enabling high-impact healthcare outcomes in precision and genomic medicine through openly-accessible and cutting-edge research services and technical expertise. Phenomics Australia is an integral part of the National Collaborative Research Infrastructure Strategy (NCRIS) funded by the Australian Government.

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Canada

Canadian Institutes of Health Research

The Canadian Institutes of Health Research (CIHR) is Canada's federal funding agency for health research. Composed of 13 Institutes, we collaborate with partners and researchers to support the discoveries and innovations that improve our health and strengthen our health care system

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Genome Canada

Genome Canada is a not-for-profit organization, funded by the Government of Canada. We act as a catalyst for developing and applying genomics+ and genomic-based technologies to create economic and social benefits for Canadians

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The Centre for Phenogenomics

TCP is a unique national resource that produces and provides tools (mouse and rat models), technology development, and services that support biomedical research across Canada and around the world.

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China

CAM-SU Genomic Resource Center, Soochow University

CAM-SU Genomic Resource Center of Soochow University is a National Center for International Research, a shared UK-Chinese mutant ES Cell Repository for Asian-Pacific research community and a platform for mouse model production and mammalian genome function deciphering to boost biomedicine research and development. In addition, CAM-SU Genomic Resource Center is constructing human-specific gene mutations in human embryonic stem cells (hESCs) via CRISPR system for disease modeling, functional annotation, and drug discovery and more. CAM-SU Genomic Research Center also conducts research in stem cells, metabolism and behavior to accelerate bioresource development.

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MARC Nanjing University

Founded in 1902, Nanjing University is one of the oldest and most prestigious institutions of higher learning in China.

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Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College

The Institute of Laboratory Animal Sciences (ILAS) is a comprehensive national research center for laboratory animals and comparative medicine. ILAS is a unique research unit that integrates the conservation, breeding, and supply of laboratory animals and animal disease models, combining the comparative study of medical technology with technical training.

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Europe

Medical Research Council, Harwell

MRC Harwell Institute comprising the Mammalian Genetics Unit, Mary Lyon Centre and Centre for Macaques is at the international forefront of the use of mammalian models to study genetics and human disease.

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Wellcome Sanger Institute

We use information from genome sequences to advance understanding of biology and improve health.

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European Bioinformatics Institute

The European Bioinformatics Institute (EMBL-EBI) is part of EMBL, Europe’s flagship laboratory for the life sciences.

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Helmholtz-Zentrum Muenchen

As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases.

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PHENOMIN

PHENOMIN is the French national Infrastructure for mouse phenogenomics that have been recognized since 2011 by the “Investissements d'Avenir” program. PHENOMIN has offered service from the generation to the comprehensive, or detailed, phenotyping, including archiving and distribution of mouse models for fundamental, biomedical and biopharmaceutical research.

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CNR Monterotondo

The CNR - Italian National Research Council - has established and developed the Core Structure of the EMMA (European Mouse Mutant Archive) Network Infrastructure since 1996 and, more recently, the new Mouse Clinic facility, at the "A. Buzzati-Traverso" International Campus, Institute of Biochemistry and Cell Biology, Monterotondo (Rome, Italy), in collaboration with the most important European Institutions for biomedical research.

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Czech Centre for Phenogenomics, IMG

The Czech Centre for Phenogenomics offers a full spectrum of genetic engineering services, strain cryopreservation, archiving services, advanced phenotyping and imaging services, as well as specific pathogen free (SPF) animal housing and husbandry.

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Universitat Autònoma de Barcelona

At UAB, the Centre of Animal Biotechnology and Gene Therapy (CBATEG) is developing gene therapy approaches for both highly-prevalent metabolic diseases (such as diabetes mellitus, insulin resistance, NASH, obesity, degenerative disease and cognitive decline), and severe rare inherited metabolic diseases (such as Lysosomal storage diseases, especially mucopolysaccharidoses). CBATEG is generating transgenic animal models of these diseases and developing adeno-associated viral vectors-mediated gene transfer-based therapeutics.

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India

Indian Institutes of Science Education and Research, Pune

IISER Pune is a research-intensive teaching institute. Our faculty and students investigate questions in science that lie beyond the boundaries of conventional thinking.

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Japan

RIKEN BioResource Research Center

RIKEN BRC is committed to receiving deposition/donation of bioresources from the research community, confirming the authenticity of bioresources by rigorous quality examination, preserving, and distributing them back to the research community. In addition, RIKEN BRC conducts research and development to accelerate active use and application of the bioresources.

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USA

The Jackson Laboratory

We are accelerating disruptive scientific breakthroughs tailored to the needs of individual patients and closing in on the genetic and molecular courses of disease.

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UC Davis

Whether UC Davis is predicting the next global virus before it happens or developing more nutritious wheat for a hungry world, our research is making the world a better place to live.

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National Institutes of Health (NIH)

The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency — making important discoveries that improve health and save lives.

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Children’s Hospital Oakland Research Institute

CHORI has the largest resource of recombinant DNA libraries across the globe, and provided 85 percent of the genes cloned for the Human Genome Project.

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Charles River Laboratories

With 80 sites around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving your product’s unique challenges.

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Baylor College of Medicine

Baylor College of Medicine is a health sciences university that creates knowledge and applies science and discoveries to further education, healthcare and community service locally and globally.

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South Africa

PCDDP North-West University

The Preclinical Drug Development Platform (PCDDP) is a state-of-the-art facility situated on the Potchefstroom campus of the North-West University in South Africa, established in 2011.

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South Korea

Korea Mouse Phenotyping Center

Korea Mouse Phenotyping Center (KMPC), funded by the Ministry of Science and ICT in South Korea, is nationwide research infrastructure to set standards for phenotyping research of mouse models of disease in Korea as well as to provide global researchers with GEM phenotype analysis technology.

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Taiwan

National Laboratory Animal Center, National Applied Research Laboratories (NARLabs)

Being the largest laboratory animal resource center in Taiwan, NLAC also acts as the foundation and key platform for the development of biotechnology industry and biomedical research. We serve as an animal breeding and testing environment that meets international standards.

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Become a member of the consortium

There are different types of membership in the consortium. The different requirements per type are listed below.

Institutional Membership

A track record of experience in high throughput phenotyping and/or large-scale knockout mouse production, allied to the physical resources to undertake such activities, or expertise in specialised (“Secondary level”) phenotyping that would add value to the resource and database.

For phenotyping centres, a commitment to phenotype at least 50 lines per year, preferably rising to 100 lines per year within the lifetime of Phase I of the IMPC programme.

For production centres, a commitment to generate at least 50 lines per year, with the ability to distribute live mice, embryos, and sperm, preferably rising to 100 lines per year within the lifetime of Phase I of the IMPC programme. For Secondary level phenotyping groups, a commitment to share data with the IMPC as a whole, and deposit the data into the IMPC Database in a timely fashion.

Agreement to work within the framework of the consortium, including commonly agreed phenotyping pipelines and IT structures. Demonstrable ability to provide the IT infrastructure for the local capture of production and/or phenotyping data and its upload to the IMPC data coordination centre(s).

Agreement to the full release of data to data coordination centres according to IMPC agreed procedures and timelines.

Agreement of production centres to provide the community access to live mice, embryos and sperm as soon as possible without intended hold backs, subject to legal or MTA restrictions.

Funders’ Membership

To commit to ensure their best endeavours to provide funding support to the IMPC programme commensurate with their institutions providing the requisite commitments to participation in the programme.

To work to facilitate smooth and harmonious integration of the research networks recommendations and guidelines.

To work to help communicate the goals and milestones of the IMPC to the wider scientific community.

Membership Fee

The membership fee is currently £50,000 GBP.

The fee may be paid, in full or in part, with in-kind contributions, or adjusted in the future subject to approval of 75% of the Steering Committee.

The membership fee shall be collected by the IMPC Administering Member and will require a separate letter of agreement to facilitate the process.

The membership fee is non-refundable.

Non-Voting Members and Observers

The Steering Committee may request individuals or institutional representatives with special skills or information to join the Steering Committee meetings on an as needed basis, or for extended periods, subject to approval of the voting membership.

Such participants will not have voting rights and may be asked to not participate in all aspects of the IMPC management and meeting discussions.

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