ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency. |
Journal of clinical medicine (September 2019) |
Adck2tm1(KOMP)Vlcg
|
PMC6780728
|
Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. |
Mammalian genome : official journal of the International Mammalian Genome Society (September 2017) |
Adgrb2tm1b(KOMP)Mbp
|
28894906
|
Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit. |
Nature communications (February 2021) |
Adgrd1tm1b(EUCOMM)Wtsi
Adgrd1tm1a(EUCOMM)Hmgu
|
PMC7902839
|
Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function. |
Nature communications (October 2016) |
Adgrf1tm1a(KOMP)Wtsi
|
PMC5075789
|
GPR110 (ADGRF1) mediates anti-inflammatory effects of N-docosahexaenoylethanolamine. |
Journal of neuroinflammation (November 2019) |
Adgrf1tm1a(KOMP)Wtsi
|
PMC6858791
|
Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury. |
International journal of molecular sciences (March 2021) |
Adgrf1tm1a(KOMP)Wtsi
|
PMC8037074
|
GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice. |
Journal of neuroinflammation (July 2021) |
Adgrf1tm1a(KOMP)Wtsi
|
PMC8286622
|
G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts. |
The Journal of biological chemistry (August 2020) |
Adgrf4tm1a(KOMP)Wtsi
Adgrf4tm1b(KOMP)Wtsi
|
32868297
|
Distribution of ASIC4 transcripts in the adult wild-type mouse brain. |
Neuroscience letters (April 2017) |
Asic4tm1a(KOMP)Mbp
|
28461138
|
Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition. |
Scientific reports (January 2017) |
Bckdktm1c(EUCOMM)Wtsi
Bckdktm1a(EUCOMM)Wtsi
Bckdktm1b(EUCOMM)Wtsi
|
PMC5209746
|
Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism. |
PloS one (July 2017) |
Bckdktm1c(EUCOMM)Wtsi
|
PMC5515431
|
BDK Deficiency in Cerebral Cortex Neurons Causes Neurological Abnormalities and Affects Endurance Capacity. |
Nutrients (July 2020) |
Bckdktm1c(EUCOMM)Wtsi
|
PMC7469005
|
INAM plays a critical role in IFN-γ production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells. |
Journal of immunology (Baltimore, Md. : 1950) (October 2014) |
Calhm6tm2a(EUCOMM)Wtsi
Calhm6tm2b(EUCOMM)Wtsi
|
25320282
|
Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice. |
PLoS genetics (August 2017) |
Cdk20tm1a(KOMP)Wtsi
|
PMC5574612
|
CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells. |
Cell reports (September 2019) |
Cdk8tm1a(EUCOMM)Hmgu
|
31509750
|
Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development. |
Development (Cambridge, England) (June 2020) |
Cdk8tm1a(EUCOMM)Hmgu
|
PMC7295591
|
NK Cell-Specific CDK8 Deletion Enhances Antitumor Responses. |
Cancer immunology research (January 2018) |
Cdk8tm1c(EUCOMM)Hmgu
|
29386186
|
Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. |
Molecular cell (September 2019) |
Cdk8tm1c(EUCOMM)Hmgu
|
31495563
|
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia. |
Nature communications (October 2019) |
Cdk8tm1c(EUCOMM)Hmgu
|
PMC6802219
|
A Murine Model for Human ECO Syndrome Reveals a Critical Role of Intestinal Cell Kinase in Skeletal Development. |
Calcified tissue international (November 2017) |
Cilk1tm1a(KOMP)Mbp
|
PMC5820141
|
Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models. |
eLife (December 2020) |
Cilk1tm1a(KOMP)Mbp
|
PMC7806262
|
Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa. |
PLoS genetics (August 2018) |
Clcc1tm1b(KOMP)Mbp
|
PMC6133373
|
ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment. |
Journal of the American Society of Nephrology : JASN (May 2020) |
Coq8btm1a(EUCOMM)Hmgu
|
32381600
|
Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS. |
Cancer cell (September 2014) |
Csnk1a1tm1c(KOMP)Wtsi
Csnk1a1tm1a(KOMP)Wtsi
|
PMC4199102
|
Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome. |
Leukemia (January 2019) |
Csnk1a1tm1c(KOMP)Wtsi
|
30651631
|
The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. |
eLife (August 2020) |
Dyrk2tm97300(L1L2_Bact_P)
|
PMC7410489
|
The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects. |
The Journal of biological chemistry (June 2020) |
Gpr139tm1.1(KOMP)Vlcg
|
32576659
|
EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia. |
Nature communications (May 2021) |
Gpr156tm1.1(KOMP)Vlcg
Ccdc88ctm1.1(KOMP)Mbp
|
PMC8129141
|
The GPR171 pathway suppresses T cell activation and limits antitumor immunity. |
Nature communications (October 2021) |
Gpr171tm1(KOMP)Vlcg
|
PMC8494883
|
GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes following Bone Marrow Transplantation. |
PloS one (July 2015) |
Gpr18tm1(KOMP)Vlcg
Gpr18tm1.1(KOMP)Vlcg
|
PMC4510063
|
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. |
Biology of sex differences (April 2018) |
Gpr37l1tm1c(EUCOMM)Wtsi
Gpr37l1tm1a(EUCOMM)Wtsi
|
PMC5889568
|
Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning. |
Neuroscience research (February 2018) |
Gprc5btm1a(EUCOMM)Wtsi
|
29481883
|
Orphan G Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling. |
Circulation (January 2020) |
Gprc5btm1a(EUCOMM)Wtsi
|
31941358
|
GPRC5b Modulates Inflammatory Response in Glomerular Diseases via NF-κB Pathway. |
Journal of the American Society of Nephrology : JASN (July 2019) |
Gprc5btm1c(EUCOMM)Wtsi
Gprc5btm1a(EUCOMM)Wtsi
|
31285284
|
HIPK4 is essential for murine spermiogenesis. |
eLife (March 2020) |
Hipk4tm1b(KOMP)Mbp
|
PMC7067585
|
Studying independent Kcna6 knock-out mice reveals toxicity of exogenous LacZ to central nociceptor terminals and differential effects of Kv1.6 on acute and neuropathic pain sensation. |
The Journal of neuroscience : the official journal of the Society for Neuroscience (September 2021) |
Kcna6em1(IMPC)J
|
34544832
|
Targeted deletion of the Kv6.4 subunit causes male sterility due to disturbed spermiogenesis. |
Reproduction, fertility, and development (August 2017) |
Kcng4tm1(KOMP)Vlcg
|
27677211
|
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. |
Neuron (December 2017) |
Kcnk13em1(IMPC)H
|
PMC5783715
|
Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice. |
Neuron (October 2017) |
Lrrk1tm1a(KOMP)Wtsi
Lrrk1tm1b(KOMP)Wtsi
|
29056298
|
ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney. |
American journal of physiology. Renal physiology (October 2014) |
Map3k5tm1a(EUCOMM)Hmgu
|
25298527
|
ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype. |
Molecular metabolism (May 2017) |
Map3k5tm1a(EUCOMM)Hmgu
|
PMC5485239
|
ASK1 inhibits browning of white adipose tissue in obesity. |
Nature communications (April 2020) |
Map3k5tm1a(EUCOMM)Hmgu
|
PMC7118089
|
Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module. |
Cell systems (November 2016) |
Mark3tm1a(KOMP)Mbp
|
PMC5269473
|
NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization. |
Nature communications (June 2018) |
Nek7tm1a(EUCOMM)Hmgu
|
PMC5997995
|
Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. |
The Journal of biological chemistry (March 2013) |
Oxgr1tm1(KOMP)Vlcg
|
PMC3630866
|
α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism. |
The Journal of clinical investigation (June 2013) |
Oxgr1tm1(KOMP)Vlcg
|
PMC3696567
|
Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. |
Journal of immunology (Baltimore, Md. : 1950) (November 2013) |
Oxgr1tm1(KOMP)Vlcg
|
PMC3869987
|
The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice. |
Biochemical and biophysical research communications (September 2016) |
Oxgr1tm1(KOMP)Vlcg
|
PMC5082686
|
Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity. |
Journal of immunology (Baltimore, Md. : 1950) (December 2017) |
Oxgr1tm1(KOMP)Vlcg
|
PMC5780246
|
The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation. |
Science immunology (October 2018) |
Oxgr1tm1(KOMP)Vlcg
|
30291131
|
The leukotriene receptors as therapeutic targets of inflammatory diseases. |
International Immunology (August 2019) |
Oxgr1tm1(KOMP)Vlcg
|
31135881
|
The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis. |
Human molecular genetics (July 2020) |
Pak3tm1b(EUCOMM)Hmgu
|
31943058
|
Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system. |
Proceedings of the National Academy of Sciences of the United States of America (June 2016) |
Pip4k2ctm1b(KOMP)Wtsi
|
PMC4941458
|
Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart. |
Advanced science (Weinheim, Baden-Wurttemberg, Germany) (March 2021) |
Pip4k2ctm1b(KOMP)Wtsi
|
PMC8132051
|
Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias. |
Nature immunology (March 2021) |
Riok2tm1a(KOMP)Wtsi
|
33753942
|
Stk31 is dispensable for embryonic development and spermatogenesis in mice. |
Molecular reproduction and development (September 2013) |
Stk31tm2a(KOMP)Wtsi
|
PMC5441557
|
Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. |
eLife (October 2019) |
Tmc4em1(IMPC)J
|
PMC6850774
|
Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability. |
PLoS genetics (December 2018) |
Ttbk2tm1a(EUCOMM)Hmgu
|
PMC6307817
|
Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility. |
Journal of cell science (November 2013) |
Ulk4tm1a(KOMP)Wtsi
|
24284070
|
Ulk4 Is Essential for Ciliogenesis and CSF Flow. |
The Journal of neuroscience : the official journal of the Society for Neuroscience (July 2016) |
Ulk4tm1a(KOMP)Wtsi
|
27445138
|
Ulk4 deficiency leads to hypomyelination in mice. |
Glia (October 2017) |
Ulk4tm1a(KOMP)Wtsi
|
29034508
|
Ulk4 regulates GABAergic signaling and anxiety-related behavior. |
Translational psychiatry (February 2018) |
Ulk4tm1a(KOMP)Wtsi
|
PMC5804027
|
Vaccinia-related kinase 2 plays a critical role in microglia-mediated synapse elimination during neurodevelopment. |
Glia (May 2019) |
Vrk2tm1d(KOMP)Wtsi
|
31050055
|