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Phenotype: decreased effector memory T-helper cell number

Definition
reduction in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype
Synonyms
reduced memory T-helper cell number
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased effector memory T-helper cell number

Total number of significant genotype-phenotype associations: 13

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult decreased effector memory T-helper cell number Resting CD4+ T helper cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult decreased effector memory T-helper cell number Effector CD4+ T helper cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Card11
Card11em1(IMPC)Ccpcz 		HOM Early adult decreased effector memory T-helper cell number Resting CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.32×10-17
Trim9
Trim9em1(IMPC)Ccpcz 		HOM Early adult decreased effector memory T-helper cell number CD4 CD44-CD62L+ T cells
Immunophenotyping		 CCP-IMG
IMPC		 5.51×10-08
Clock
Clockem1(IMPC)Ccpcz 		HOM Early adult decreased effector memory T-helper cell number Resting CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.81×10-06
Hcar1
Hcar1em1(IMPC)Ccpcz 		HOM Early adult decreased effector memory T-helper cell number CD4 CD44-CD62L+ T cells
Immunophenotyping		 CCP-IMG
IMPC		 4.74×10-06
Asb2
Asb2tm2b(KOMP)Wtsi 		HET   Early adult decreased effector memory T-helper cell number CD4 CD44-CD62L+ T cells
Immunophenotyping		 KMPC
IMPC		 5.15×10-06
Tmem60
Tmem60em1(IMPC)Ccpcz 		HOM Early adult decreased effector memory T-helper cell number CD4 CD44-CD62L+ T cells
Immunophenotyping		 CCP-IMG
IMPC		 1.96×10-05
Flt3
Flt3em1(IMPC)Ccpcz 		HOM Early adult decreased effector memory T-helper cell number Resting CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.53×10-05
Psmb11
Psmb11em1(IMPC)Ccpcz 		HOM Early adult decreased effector memory T-helper cell number Resting CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.80×10-05
Cd38
Cd38em1(IMPC)Ccpcz 		HOM   Early adult decreased effector memory T-helper cell number Effector CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 7.37×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
FACS
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping

 Phenotype associations stats

1.40% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased effector memory T-helper cell number (11/786)

1.47% females (5/340) 1.18% males (4/340)

Select a parameter    



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