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Phenotype: decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number

Definition
reduction in the number of the CD4+, CD25+ alpha-beta regulatory T cells with a CD44+ CD62L- memory phenotype
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number

Total number of significant genotype-phenotype associations: 2

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00

Download data as:   TSV   XLS

 The way we measure

Procedure
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping

 Phenotype associations stats

0.43% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number (2/461)

0.00% females (0/6) 0.00% males (0/6)

Select a parameter    



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