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Phenotype: increased effector memory CD8-positive, alpha-beta T cell number

Definition
increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative
Synonyms
increased effector CD8-positive, alpha-beta memory T-cell number,  increased effector memory CD8-positive, alpha-beta T-lymphocyte number,  increased effector CD8-positive, alpha-beta memory T cell number,  increased effector CD8-positive, alpha-beta memory T-lymphocyte number,  increased effector memory CD8-positive, alpha-beta T lymphocyte number,  increased effector CD8-positive, alpha-beta memory T lymphocyte number,  increased effector memory CD8-positive, alpha-beta T-cell number
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased effector memory CD8-positive, alpha-beta T cell number

Total number of significant genotype-phenotype associations: 21

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult increased effector memory CD8-positive, alpha-beta T cell number Resting CD8+ T cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased effector memory CD8-positive, alpha-beta T cell number Effector CD8+ T cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased effector memory CD8-positive, alpha-beta T cell number Resting CD8+ T cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult increased effector memory CD8-positive, alpha-beta T cell number Resting CD8+ T cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi 		HOM   Early adult increased effector memory CD8-positive, alpha-beta T cell number Effector CD8+ T cells - % of CD8+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Pepd
Pepdtm1a(KOMP)Wtsi 		HOM   Early adult increased effector memory CD8-positive, alpha-beta T cell number Resting CD8+ T cells - % of CD8+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Psmb11
Psmb11em1(IMPC)Ccpcz 		HOM Early adult increased effector memory CD8-positive, alpha-beta T cell number Naïve CD8+ T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.24×10-21
Tmprss6
Tmprss6tm1b(EUCOMM)Wtsi 		HOM Early adult increased effector memory CD8-positive, alpha-beta T cell number CD8 CD44+CD62L+ T cells
Immunophenotyping		 ICS
IMPC		 2.39×10-10
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult increased effector memory CD8-positive, alpha-beta T cell number CD8 CD44+CD62L- T cells
Immunophenotyping		 HMGU
IMPC		 1.54×10-08
Nxn
Nxntm1b(EUCOMM)Wtsi 		HET Early adult increased effector memory CD8-positive, alpha-beta T cell number Effector CD8+ T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.13×10-07
Parp1
Parp1tm1b(EUCOMM)Hmgu 		HOM   Early adult increased effector memory CD8-positive, alpha-beta T cell number CD8 CD44+CD62L+ T cells
Immunophenotyping		 ICS
IMPC		 2.08×10-06
Cd38
Cd38em1(IMPC)Ccpcz 		HOM   Early adult increased effector memory CD8-positive, alpha-beta T cell number Effector CD8+ T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 6.63×10-06
Pank2
Pank2em1(IMPC)Ccpcz 		HOM   Early adult increased effector memory CD8-positive, alpha-beta T cell number Naïve CD8+ T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.83×10-05
Tnfrsf1a
Tnfrsf1aem1(IMPC)Ccpcz 		HOM Early adult increased effector memory CD8-positive, alpha-beta T cell number Effector CD8+ T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.46×10-05
Cpm
Cpmem1(IMPC)Ccpcz 		HOM Early adult increased effector memory CD8-positive, alpha-beta T cell number Naïve CD8+ T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.09×10-05
Spred1
Spred1em1(IMPC)Ccpcz 		HOM   Early adult increased effector memory CD8-positive, alpha-beta T cell number Effector CD8+ T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.22×10-05
Apbb1ip
Apbb1ipem1(IMPC)Ccpcz 		HOM Early adult increased effector memory CD8-positive, alpha-beta T cell number Naïve CD8+ T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 6.29×10-05
Nub1
Nub1tm1b(EUCOMM)Hmgu 		HOM Early adult increased effector memory CD8-positive, alpha-beta T cell number CD8 CD44+CD62L+ T cells
Immunophenotyping		 CCP-IMG
IMPC		 8.38×10-05
Ube3c
Ube3ctm1b(EUCOMM)Hmgu 		HOM   Early adult increased effector memory CD8-positive, alpha-beta T cell number CD8 CD44+CD62L+ T cells
Immunophenotyping		 HMGU
IMPC		 8.44×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
Buffy coat peripheral blood leukocyte immunophenotyping
FACS
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

2.26% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased effector memory CD8-positive, alpha-beta T cell number (18/797)

1.16% females (4/345) 1.74% males (6/345)

Select a parameter    



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