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Phenotype: decreased circulating amylase level

Definition
reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood
Synonyms
decreased circulating diastase level,  reduced circulating amylase level
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased circulating amylase level

Total number of significant genotype-phenotype associations: 38

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Cpgi5563
Cpgi5563tm1.1(NCC)WCS 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 3.26×10-27
Gna11
Gna11tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 MRC Harwell
EuroPhenome		 7.38×10-14
Cbr2
Cbr2tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 3.60×10-11
Wac
Wactm2b(EUCOMM)Wtsi 		HET Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 1.07×10-09
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 4.89×10-09
Phex
Phexnot yet available 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 HMGU
EuroPhenome		 1.08×10-08
Myo6
Myo6Tlc 		HET Early adult decreased circulating amylase level Alpha-amylase
Clinical chemistry (GMC)		 HMGU
EuroPhenome		 2.24×10-08
Chd9
Chd9tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 2.30×10-08
Setd1b
Setd1btm1.2(IMPC)Wtsi 		HET Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 3.35×10-08
Hr
Hrem1(IMPC)H 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 MRC Harwell
IMPC		 3.97×10-08
Pde6b
Pde6bPde6b 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical chemistry (GMC)		 HMGU
EuroPhenome		 2.14×10-07
Vat1l
Vat1ltm1a(EUCOMM)Hmgu 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 ICS
EuroPhenome		 2.95×10-07
Mtarc2
Mtarc2tm2a(EUCOMM)Hmgu 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 ICS
EuroPhenome		 9.06×10-07
Ush1c
Ush1ctm1a(KOMP)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 1.07×10-06
Mib2
Mib2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 ICS
EuroPhenome		 3.47×10-06
Mysm1
Mysm1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 HMGU
EuroPhenome		 4.12×10-06
Celsr1
Celsr1Scy 		HET Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 MRC Harwell
EuroPhenome		 6.46×10-06
Cyba
Cybatm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 6.58×10-06
Strbp
Strbpem1(IMPC)Hmgu 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 HMGU
IMPC		 9.28×10-06
Izumo1r
Izumo1rtm2a(KOMP)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 1.23×10-05
Gimap6
Gimap6tm1a(KOMP)Wtsi 		HOM   Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 1.28×10-05
Mybpc3
Mybpc3tm1a(EUCOMM)Hmgu 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 MRC Harwell
EuroPhenome		 1.40×10-05
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 ICS
EuroPhenome		 1.71×10-05
Gdap2
Gdap2em1(IMPC)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 1.85×10-05
Fbn2
Fbn2em1(IMPC)Rbrc 		HOM   Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 RBRC
IMPC		 1.93×10-05
Cisd2
Cisd2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 MRC Harwell
EuroPhenome		 2.52×10-05
Usp54
Usp54tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 MRC Harwell
IMPC		 2.78×10-05
Col4a3
Col4a3tm1b(EUCOMM)Wtsi 		HOM   Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 MRC Harwell
IMPC		 4.30×10-05
Col1a2
Col1a2tm1b(EUCOMM)Wtsi 		HOM   Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 MRC Harwell
IMPC		 5.18×10-05
Ppp3ca
Ppp3catm2e(EUCOMM)Wtsi 		HOM   Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
MGP		 6.22×10-05
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HOM   Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 RBRC
IMPC		 7.03×10-05
Trpc3
Trpc3Mwk 		HET   Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 MRC Harwell
EuroPhenome		 7.11×10-05
Mindy1
Mindy1tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
EuroPhenome		 7.30×10-05
Cgas
Cgastm1a(EUCOMM)Hmgu 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 ICS
EuroPhenome		 8.25×10-05
Sfpq
Sfpqtm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 WTSI
IMPC		 8.47×10-05
Nrgn
Nrgnem1(IMPC)H 		HOM Early adult decreased circulating amylase level Alpha-amylase
Clinical Chemistry		 MRC Harwell
IMPC		 9.44×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Clinical chemistry (GMC)
Fasted Bleed
Terminal Bleed

 Phenotype associations stats

1.22% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating amylase level (36/2959)

0.07% females (2/2963) 0.95% males (28/2945)

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