Definition
reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity
Synonyms
decreased number of immature B cells,
decreased number of immature B-lymphocytes,
decreased number of immature B-cells,
decreased number of immature B lymphocytes,
reduced immature B cell number
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with decreased immature B cell number
Total number of significant genotype-phenotype associations: 10
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Arpc1b Arpc1btm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased transitional stage T2 B cell number | Transitional 2 B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Cog6 Cog6tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased transitional stage T2 B cell number | Transitional 2 B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Cttnbp2 Cttnbp2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased transitional stage T1 B cell number | Transitional 1 B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Cxcr2 Cxcr2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased immature B cell number | Immature B cells (Hardy fraction E) - % of CD45+ Bone marrow immunophenotyping |
WTSI 3i |
0.00 | |
| Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased immature B cell number | Immature B cells (Hardy fraction E) - % of CD45+ Bone marrow immunophenotyping |
WTSI 3i |
0.00 | |
| Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased transitional stage T1 B cell number | Transitional 1 B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased transitional stage T2 B cell number | Transitional 2 B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Pepd Pepdtm1a(KOMP)Wtsi |
HOM | Early adult | decreased immature B cell number | Immature B cells (Hardy fraction E) - % of B220+ Bone marrow immunophenotyping |
WTSI 3i |
0.00 | |
| Pepd Pepdtm1a(KOMP)Wtsi |
HOM | Early adult | decreased transitional stage T1 B cell number | Transitional 1 B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Bach2 Bach2tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased transitional stage B cell number | Transitional B Cells (CD21/35 low) Immunophenotyping |
HMGU IMPC |
1.86×10-05 |