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Phenotype: decreased spleen weight

Definition
reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets
Synonyms
reduced spleen weight
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased spleen weight

Total number of significant genotype-phenotype associations: 44

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Msi2
Msi2em1(IMPC)Mbp 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 2.22×10-26
Blnk
Blnkem1(IMPC)H 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 2.73×10-11
Tm4sf20
Tm4sf20em1(IMPC)Bay 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 9.86×10-11
Mul1
Mul1em1(IMPC)H 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 2.87×10-09
Lep
Leptm1b(EUCOMM)Hmgu 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 4.84×10-09
Lepr
Leprtm1b(EUCOMM)Wtsi 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 3.90×10-08
Trim50
Trim50tm1b(KOMP)Wtsi 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 7.99×10-08
Gh
Ghtm1.1(KOMP)Vlcg 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 9.66×10-08
Trp73
Trp73em1(IMPC)H 		HET Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.64×10-07
Zfp160
Zfp160tm1b(EUCOMM)Wtsi 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 7.48×10-07
Abhd13
Abhd13em1(IMPC)Mbp 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 1.21×10-06
Tpo
Tpoem1(IMPC)H 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.64×10-06
Tbc1d8b
Tbc1d8bem1(IMPC)Bay 		HEM Early adult decreased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 2.07×10-06
Fbxl3
Fbxl3em1(IMPC)Ccpcz 		HOM   Early adult decreased spleen weight Spleen weight
Organ Weight		 CCP-IMG
IMPC		 3.01×10-06
Kcnma1
Kcnma1em1(IMPC)H 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 4.57×10-06
Itga11
Itga11em1(IMPC)H 		HOM   Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 5.80×10-06
Trim9
Trim9em1(IMPC)Ccpcz 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 CCP-IMG
IMPC		 7.29×10-06
Rnf10
Rnf10tm1b(KOMP)Wtsi 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.08×10-05
Pou2af1
Pou2af1tm1b(KOMP)Wtsi 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 1.16×10-05
Nsun5
Nsun5tm2b(EUCOMM)Wtsi 		HOM Late adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.40×10-05
Rab39b
Rab39bem1(IMPC)Tcp 		HEM Late adult decreased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 1.47×10-05
Clstn3
Clstn3tm1b(EUCOMM)Hmgu 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 1.55×10-05
Eif4g1
Eif4g1em1(IMPC)Hmgu 		HET Early adult decreased spleen weight Spleen weight
Organ Weight		 HMGU
IMPC		 1.97×10-05
Fastkd2
Fastkd2tm1b(EUCOMM)Wtsi 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 BCM
IMPC		 2.06×10-05
Clock
Clockem1(IMPC)Ccpcz 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 CCP-IMG
IMPC		 2.08×10-05
Snd1
Snd1em1(IMPC)Tcp 		HET Late adult decreased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 2.13×10-05
Usp45
Usp45em1(IMPC)H 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 2.23×10-05
Rnf168
Rnf168em1(IMPC)H 		HOM   Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 3.13×10-05
Afdn
Afdnem1(IMPC)Mbp 		HET Early adult decreased spleen weight Spleen weight
Organ Weight		 UC Davis
IMPC		 4.88×10-05
Card11
Card11em1(IMPC)Ccpcz 		HOM   Early adult decreased spleen weight Spleen weight
Organ Weight		 CCP-IMG
IMPC		 5.86×10-05
Cul4a
Cul4atm1b(EUCOMM)Hmgu 		HOM   Early adult decreased spleen weight Spleen weight
Organ Weight		 CCP-IMG
IMPC		 5.94×10-05
Vgf
Vgfem1(IMPC)H 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 6.36×10-05
Pcm1
Pcm1em1(IMPC)Tcp 		HOM   Early adult decreased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 7.10×10-05
Ctss
Ctssem1(IMPC)H 		HOM   Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 7.13×10-05
Adh5
Adh5tm1b(EUCOMM)Wtsi 		HOM   Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 7.45×10-05
Elmod1
Elmod1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 7.47×10-05
Scand1
Scand1em1(IMPC)H 		HOM Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 8.24×10-05
Tenm4
Tenm4em1(IMPC)Tcp 		HOM Late adult decreased spleen weight Spleen weight
Organ Weight		 TCP
IMPC		 9.18×10-05
Pard3
Pard3tm1b(KOMP)Wtsi 		HET Early adult decreased spleen weight Spleen weight
Organ Weight		 MRC Harwell
IMPC		 9.55×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Organ Weight

 Phenotype associations stats

1.20% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased spleen weight (39/3255)

0.50% females (13/2611) 0.72% males (23/3210)

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