IMPC Gene variants with abnormal spine curvature
Total number of significant genotype-phenotype associations: 76
Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
---|---|---|---|---|---|---|---|
Sik3 Sik3tm1a(EUCOMM)Hmgu |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
WTSI IMPC |
2.50×10-11 | |
Ccnd2 Ccnd2tm1b(KOMP)Mbp |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
MRC Harwell IMPC |
1.18×10-10 | |
Sik3 Sik3tm1a(EUCOMM)Hmgu |
HOM | Early adult | kyphosis | Kyphosis X-ray |
WTSI IMPC |
2.71×10-10 | |
Uchl1 Uchl1tm1b(EUCOMM)Hmgu |
HET | Early adult | abnormal spine curvature | Shape of spine X-ray |
MRC Harwell IMPC |
1.77×10-08 | |
Slc20a2 Slc20a2tm1a(EUCOMM)Wtsi |
HOM | Early adult | kyphosis | Kyphosis X-ray |
WTSI IMPC |
5.58×10-08 | |
Fgf14 Fgf14em1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
2.11×10-07 | |
Krtap8-1 Krtap8-1em1(IMPC)Ccpcz |
HOM | Early adult | lordosis | Lordosis X-ray |
CCP-IMG IMPC |
2.24×10-07 | |
Cer1 Cer1em1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
3.05×10-07 | |
Krt27 Krt27em1(IMPC)Ccpcz |
HOM | Early adult | lordosis | Lordosis X-ray |
CCP-IMG IMPC |
5.77×10-07 | |
Slc20a2 Slc20a2tm1a(EUCOMM)Wtsi |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
WTSI IMPC |
6.47×10-07 | |
Prss35 Prss35em1(IMPC)Ccpcz |
HOM | Early adult | lordosis | Lordosis X-ray |
CCP-IMG IMPC |
6.86×10-07 | |
Ccnd2 Ccnd2tm1b(KOMP)Mbp |
HOM | Late adult | abnormal spine curvature | Shape of spine X-ray |
MRC Harwell IMPC |
1.61×10-06 | |
Ddi2 Ddi2tm1b(EUCOMM)Hmgu |
HET | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
1.96×10-06 | |
Tent5a Tent5aem1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
1.96×10-06 | |
Rnf14 Rnf14em1(IMPC)Ccpcz |
HOM | Early adult | lordosis | Lordosis X-ray |
CCP-IMG IMPC |
2.13×10-06 | |
Calb1 Calb1em1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
2.35×10-06 | |
Mfng Mfngem1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
2.35×10-06 | |
Tram2 Tram2tm1a(KOMP)Wtsi |
HOM | Early adult | kyphosis | Kyphosis X-ray |
WTSI IMPC |
2.92×10-06 | |
Bbip1 Bbip1em1(IMPC)Ccpcz |
HET | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
3.11×10-06 | |
Bmp6 Bmp6em1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
3.11×10-06 | |
Zc3h8 Zc3h8em1(IMPC)Ccpcz |
HET | Early adult | lordosis | Lordosis X-ray |
CCP-IMG IMPC |
3.61×10-06 | |
Ak7 Ak7em1(IMPC)Ccpcz |
HET | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
3.90×10-06 | |
Nisch Nischtm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
MRC Harwell IMPC |
4.45×10-06 | |
Bbip1 Bbip1em1(IMPC)Ccpcz |
HET | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
6.29×10-06 | |
Bmp6 Bmp6em1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
6.29×10-06 | |
Mir129-2 Mir129-2em1(IMPC)Kmpc |
HOM | Late adult | abnormal spine curvature | Shape of spine X-ray |
KMPC IMPC |
7.30×10-06 | |
Rnf168 Rnf168tm2b(EUCOMM)Hmgu |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
7.34×10-06 | |
Ropn1l Ropn1ltm1b(EUCOMM)Wtsi |
HOM | Early adult | kyphosis | Kyphosis X-ray |
WTSI IMPC |
7.53×10-06 | |
Wdr37 Wdr37tm1a(KOMP)Wtsi |
HOM | Early adult | kyphosis | Kyphosis X-ray |
WTSI IMPC |
7.53×10-06 | |
Arg2 Arg2em1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
8.98×10-06 | |
Cer1 Cer1em1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
8.98×10-06 | |
Arg2 Arg2em1(IMPC)Ccpcz |
HOM | Early adult | lordosis | Lordosis X-ray |
CCP-IMG IMPC |
9.21×10-06 | |
Brinp3 Brinp3em1(IMPC)Ccpcz |
HOM | Early adult | lordosis | Lordosis X-ray |
CCP-IMG IMPC |
9.21×10-06 | |
Btbd7 Btbd7em1(IMPC)Ccpcz |
HOM | Early adult | lordosis | Lordosis X-ray |
CCP-IMG IMPC |
9.21×10-06 | |
Prss54 Prss54em1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
9.72×10-06 | |
Tram2 Tram2tm1a(KOMP)Wtsi |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
WTSI IMPC |
1.08×10-05 | |
Zc2hc1c Zc2hc1cem1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
1.16×10-05 | |
Pstpip1 Pstpip1em1(IMPC)Ccpcz |
HOM | Early adult | lordosis | Lordosis X-ray |
CCP-IMG IMPC |
1.29×10-05 | |
Prss21 Prss21em1(IMPC)Ccpcz |
HET | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
1.43×10-05 | |
Tpte Tpteem1(IMPC)Kmpc |
HOM | Early adult | kyphosis | Kyphosis X-ray |
KMPC IMPC |
1.51×10-05 | |
Tpte Tpteem1(IMPC)Kmpc |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
KMPC IMPC |
1.51×10-05 | |
Kcnv2 Kcnv2tm1Wtsi |
HOM | Early adult | kyphosis | Kyphosis X-ray |
WTSI IMPC |
1.79×10-05 | |
Fam53a Fam53aem1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
1.85×10-05 | |
Prss54 Prss54em1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
1.85×10-05 | |
Mbd1 Mbd1em1(IMPC)Wtsi |
HOM | Early adult | lordosis | Lordosis X-ray |
WTSI IMPC |
1.90×10-05 | |
Krt72 Krt72em1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
2.05×10-05 | |
Rnf148 Rnf148em1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
2.05×10-05 | |
Calb1 Calb1em1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
2.51×10-05 | |
Mfng Mfngem1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
2.51×10-05 | |
Krt72 Krt72em1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
2.64×10-05 | |
Rnf148 Rnf148em1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
2.64×10-05 | |
Prss21 Prss21em1(IMPC)Ccpcz |
HET | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
2.70×10-05 | |
Klhl1 Klhl1em1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
2.86×10-05 | |
Adk Adkem1(IMPC)Ccpcz |
HET | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
3.04×10-05 | |
Fam221a Fam221aem1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
3.04×10-05 | |
Fgf14 Fgf14em1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
3.67×10-05 | |
Prss35 Prss35em1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
3.71×10-05 | |
Tent5a Tent5aem1(IMPC)Ccpcz |
HOM | Early adult | scoliosis | Scoliosis X-ray |
CCP-IMG IMPC |
4.35×10-05 | |
Dnase1l2 Dnase1l2tm1.1(KOMP)Wtsi |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
WTSI IMPC |
5.04×10-05 | |
H2-Eb1 H2-Eb1b-tm1a(KOMP)Wtsi |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
WTSI IMPC |
5.04×10-05 | |
Pabpc4 Pabpc4tm1a(KOMP)Wtsi |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
WTSI IMPC |
5.04×10-05 | |
Ropn1l Ropn1ltm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
WTSI IMPC |
5.04×10-05 | |
Selenok Selenoktm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
WTSI IMPC |
5.04×10-05 | |
Wdr37 Wdr37tm1a(KOMP)Wtsi |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
WTSI IMPC |
5.04×10-05 | |
Fnip1 Fnip1em1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
5.36×10-05 | |
Fam221a Fam221aem1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
5.71×10-05 | |
Prss21 Prss21em1(IMPC)Ccpcz |
HET | Early adult | lordosis | Lordosis X-ray |
CCP-IMG IMPC |
7.34×10-05 | |
Arg2 Arg2em1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
7.66×10-05 | |
Klhl1 Klhl1em1(IMPC)Ccpcz |
HOM | Early adult | kyphosis | Kyphosis X-ray |
CCP-IMG IMPC |
7.66×10-05 | |
Ak7 Ak7em1(IMPC)Ccpcz |
HET | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
8.11×10-05 | |
Vgll3 Vgll3em1(IMPC)H |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
MRC Harwell IMPC |
9.20×10-05 | |
Zc2hc1c Zc2hc1cem1(IMPC)Ccpcz |
HOM | Early adult | abnormal spine curvature | Shape of spine X-ray |
CCP-IMG IMPC |
9.29×10-05 |