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Phenotype: prolonged PR interval

Definition
increase in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex
Synonyms
prolonged PR-interval
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged PR interval

Total number of significant genotype-phenotype associations: 14

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Cdk20
Cdk20em1(IMPC)Bay 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 2.02×10-38
Shmt2
Shmt2em1(IMPC)Bay 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 4.80×10-31
Eral1
Eral1em1(IMPC)Bay 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 1.27×10-20
Usp53
Usp53em1(IMPC)Tcp 		HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 TCP
IMPC		 1.65×10-09
Pigq
Pigqtm2b(EUCOMM)Wtsi 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 1.69×10-08
Cbl
Cbltm1b(EUCOMM)Hmgu 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 ICS
IMPC		 9.85×10-08
Il2ra
Il2ratm1b(EUCOMM)Wtsi 		HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 ICS
IMPC		 2.61×10-06
Rex1bd
Rex1bdem1(IMPC)J 		HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 3.72×10-05
Dennd5b
Dennd5bem1(IMPC)Tcp 		HOM   Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 TCP
IMPC		 3.88×10-05
Snca
Sncaem1(IMPC)H 		HOM Late adult prolonged PR interval PR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 4.79×10-05
Rab33b
Rab33bem1(IMPC)J 		HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 4.99×10-05
Gxylt1
Gxylt1em1(IMPC)Bay 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 5.52×10-05
Synpo2
Synpo2tm1b(EUCOMM)Wtsi 		HET   Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 ICS
IMPC		 6.97×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Electrocardiogram (ECG)

 Phenotype associations stats

0.22% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged PR interval (13/6012)

0.10% females (6/5972) 0.10% males (6/5963)

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