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Phenotype: prolonged QT interval

Definition
increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave
Synonyms
increased QT interval,  widened QT interval
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged QT interval

Total number of significant genotype-phenotype associations: 21

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Pla2g10
Pla2g10tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 HMGU
IMPC		 2.22×10-14
Iah1
Iah1tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 ICS
IMPC		 3.76×10-10
Dennd5b
Dennd5bem1(IMPC)Tcp 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 TCP
IMPC		 5.55×10-09
Gatm
Gatmtm1b(KOMP)Wtsi 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 HMGU
IMPC		 9.78×10-09
Rxfp2
Rxfp2tm1b(EUCOMM)Wtsi 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 HMGU
IMPC		 5.09×10-07
Ypel2
Ypel2em1(IMPC)Tcp 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 TCP
IMPC		 2.45×10-06
Sun5
Sun5em1(IMPC)Mbp 		HOM Late adult prolonged QT interval QT
Electrocardiogram (ECG)		 UC Davis
IMPC		 3.84×10-06
Clcf1
Clcf1tm1.1(KOMP)Vlcg 		HET Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 TCP
IMPC		 1.35×10-05
Klf16
Klf16em1(IMPC)J 		HET   Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 JAX
IMPC		 1.45×10-05
Zfp804a
Zfp804aem1(IMPC)Tcp 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 TCP
IMPC		 1.52×10-05
Btnl4
Btnl4em1(IMPC)Tcp 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 TCP
IMPC		 2.02×10-05
Cap2
Cap2tm1b(EUCOMM)Wtsi 		HET Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 HMGU
IMPC		 2.11×10-05
Tmem60
Tmem60em1(IMPC)Ccpcz 		HOM   Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 CCP-IMG
IMPC		 2.23×10-05
Mob1a
Mob1aem1(IMPC)Bay 		HET Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 BCM
IMPC		 2.88×10-05
Ap1s3
Ap1s3em1(IMPC)Bay 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 BCM
IMPC		 3.51×10-05
Sh3tc1
Sh3tc1tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 ICS
IMPC		 3.76×10-05
Vdac3
Vdac3em1(IMPC)Hmgu 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 HMGU
IMPC		 3.91×10-05
Klhl29
Klhl29tm1b(EUCOMM)Hmgu 		HET Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 ICS
IMPC		 4.12×10-05
Ssh2
Ssh2em1(IMPC)J 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 JAX
IMPC		 4.78×10-05
Col6a3
Col6a3em1(IMPC)Tcp 		HOM Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 TCP
IMPC		 5.87×10-05
Ntf5
Ntf5tm1b(EUCOMM)Hmgu 		HOM   Early adult prolonged QT interval QT
Electrocardiogram (ECG)		 ICS
IMPC		 9.13×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Electrocardiogram (ECG)

 Phenotype associations stats

0.49% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged QT interval (21/4315)

0.16% females (7/4293) 0.26% males (11/4291)

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