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Phenotype: decreased circulating chloride level

Definition
reduced chloride concentration in the blood
Synonyms
reduced circulating chloride level,  hypochloremia,  hypochloraemia
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased circulating chloride level

Total number of significant genotype-phenotype associations: 64

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Slc12a1
Slc12a1urehr3 		HOM Early adult decreased circulating chloride level Chloride
Clinical chemistry (GMC)		 HMGU
EuroPhenome		 1.43×10-11
Lepr
Leprtm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 MRC Harwell
IMPC		 3.72×10-11
Dll1
Dll1tm1Gos 		HET Early adult decreased circulating chloride level Chloride
Clinical chemistry (GMC)		 HMGU
EuroPhenome		 1.66×10-10
Vmp1
Vmp1not yet available 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 HMGU
EuroPhenome		 2.72×10-10
Cpe
Cpetm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 HMGU
IMPC		 1.92×10-09
Kmt2d
Kmt2dtm1.2(IMPC)Wtsi 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 1.13×10-08
Unc80
Unc80em1(IMPC)Tcp 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 TCP
IMPC		 1.09×10-07
Farsa
Farsatm2a(EUCOMM)Wtsi 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 1.66×10-07
Eif4g2
Eif4g2tm1b(KOMP)Wtsi 		HET   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 3.65×10-07
Cul4a
Cul4atm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 7.60×10-07
Lrba
Lrbaem1(IMPC)Wtsi 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 7.75×10-07
Ap4e1
Ap4e1tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 9.54×10-07
Cpa2
Cpa2tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 HMGU
IMPC		 1.13×10-06
Vsx1
Vsx1em1(IMPC)Ccpcz 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 1.29×10-06
Rin3
Rin3tm1.1(KOMP)Vlcg 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 1.30×10-06
Psg25
Psg25em1(IMPC)Wtsi 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 1.30×10-06
Aqp1
Aqp1tm1b(EUCOMM)Wtsi 		HOM Late adult decreased circulating chloride level Chloride
Clinical Chemistry		 MRC Harwell
IMPC		 1.63×10-06
Rnf25
Rnf25tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 1.70×10-06
Dusp4
Dusp4tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
MGP		 2.73×10-06
Tbc1d4
Tbc1d4tm1b(EUCOMM)Hmgu 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 2.78×10-06
Slc25a4
Slc25a4tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 3.10×10-06
Krt1
Krt1em1(IMPC)Ccpcz 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 3.56×10-06
Atf2
Atf2tm1b(EUCOMM)Hmgu 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 3.68×10-06
Abhd8
Abhd8tm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 BCM
IMPC		 4.30×10-06
Stk39
Stk39tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
MGP		 4.33×10-06
Proser2
Proser2em1(IMPC)Ccpcz 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 4.55×10-06
Apoc4
Apoc4tm1.1(KOMP)Mbp 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 HMGU
IMPC		 4.77×10-06
Zbtb24
Zbtb24tm1b(EUCOMM)Hmgu 		HET   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 HMGU
IMPC		 4.85×10-06
Hspa5
Hspa5tm1.1(KOMP)Vlcg 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 6.22×10-06
Phip
Phipem1(IMPC)Wtsi 		HET   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 6.47×10-06
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 1.07×10-05
Gar1
Gar1tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 ICS
EuroPhenome		 1.25×10-05
Stx19
Stx19tm1.1(KOMP)Vlcg 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 1.29×10-05
Hmbox1
Hmbox1em1(IMPC)Tcp 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 TCP
IMPC		 1.35×10-05
Chn1
Chn1tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 1.49×10-05
Asb1
Asb1em1(IMPC)Ccpcz 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 1.53×10-05
Cstdc2
Cstdc2em1(IMPC)Tcp 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 TCP
IMPC		 1.57×10-05
Eif4enif1
Eif4enif1em1(IMPC)Tcp 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 TCP
IMPC		 1.70×10-05
Tmt1b
Tmt1btm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 1.88×10-05
Krt34
Krt34em1(IMPC)Ccpcz 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 2.08×10-05
Ptges2
Ptges2tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
EuroPhenome		 2.13×10-05
Ipp
Ipptm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 2.25×10-05
Acsm2
Acsm2tm1.1(KOMP)Vlcg 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 2.67×10-05
Ppp1r35
Ppp1r35tm1.1(KOMP)Vlcg 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 2.79×10-05
Wfdc18
Wfdc18tm1a(KOMP)Wtsi 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 3.33×10-05
Rnf144a
Rnf144aem1(IMPC)Tcp 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 TCP
IMPC		 3.58×10-05
Foxo3
Foxo3tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 3.78×10-05
Hsd17b1
Hsd17b1tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 4.12×10-05
Adad1
Adad1em1(IMPC)J 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 4.32×10-05
Insig1
Insig1em1(IMPC)Ccpcz 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 4.62×10-05
Aldh16a1
Aldh16a1tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 4.93×10-05
Kctd10
Kctd10Gt(RRG305)Byg 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
MGP		 5.19×10-05
Skic2
Skic2tm2b(EUCOMM)Wtsi 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 BCM
IMPC		 5.66×10-05
Btbd8
Btbd8em1(IMPC)Ccpcz 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 6.32×10-05
Agpat1
Agpat1tm1.1(KOMP)Vlcg 		HET   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 6.41×10-05
Acsl4
Acsl4tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
MGP		 7.07×10-05
Rad21l
Rad21ltm1b(KOMP)Wtsi 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 7.18×10-05
Cyb561
Cyb561tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 MRC Harwell
EuroPhenome		 8.39×10-05
Gipc3
Gipc3tm1b(KOMP)Wtsi 		HOM   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 9.79×10-05
Adcy9
Adcy9tm1b(EUCOMM)Wtsi 		HET   Early adult decreased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 9.83×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Clinical chemistry (GMC)
Fasted Bleed
Terminal Bleed
Urine Analysis

 Phenotype associations stats

1.58% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating chloride level (60/3801)

0.67% females (25/3744) 0.51% males (19/3713)

Select a parameter    



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