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Phenotype: increased circulating chloride level

Definition
elevated chloride concentration in the blood
Synonyms
hyperchloremia,  hyperchloraemia
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased circulating chloride level

Total number of significant genotype-phenotype associations: 86

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Tmem237
Tmem237tm1b(EUCOMM)Hmgu 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 7.20×10-32
Herc1
Herc1em3(IMPC)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 1.11×10-19
Kifbp
Kifbptm1a(KOMP)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 1.81×10-19
Rbmx
Rbmxtm2b(KOMP)Wtsi 		HEM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 4.44×10-16
Ehd1
Ehd1tm1a(EUCOMM)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
MGP		 5.44×10-13
Slc29a3
Slc29a3em1(IMPC)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 1.70×10-12
Gimap6
Gimap6tm1a(KOMP)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 1.64×10-11
Cdh23
Cdh23tm2b(EUCOMM)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 1.08×10-10
Cdca5
Cdca5tm1.1(KOMP)Vlcg 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 4.30×10-10
Ift20
Ift20tm1a(EUCOMM)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 ICS
EuroPhenome		 9.55×10-10
Zbtb4
Zbtb4tm1.1(KOMP)Vlcg 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 4.56×10-09
Dach1
Dach1tm1b(KOMP)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 4.53×10-08
Cish
Cishtm1a(KOMP)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
MGP		 6.02×10-08
Dcx
Dcxtm1a(EUCOMM)Wtsi 		HEM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 6.81×10-08
Nfat5
Nfat5tm1b(KOMP)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 6.83×10-08
Myo7b
Myo7btm1b(EUCOMM)Hmgu 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 1.17×10-07
Cbx6
Cbx6tm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 2.66×10-07
Dbn1
Dbn1tm1b(KOMP)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 2.70×10-07
Knop1
Knop1tm1b(EUCOMM)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 BCM
IMPC		 3.65×10-07
Ush1c
Ush1ctm1a(KOMP)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 4.17×10-07
Acat2
Acat2tm1b(KOMP)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 BCM
IMPC		 7.81×10-07
Elmod1
Elmod1tm1a(EUCOMM)Hmgu 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 MRC Harwell
EuroPhenome		 9.19×10-07
Kif1b
Kif1btm1b(KOMP)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 9.32×10-07
Gad2
Gad2tm1b(EUCOMM)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 HMGU
IMPC		 1.83×10-06
Cacna1i
Cacna1itm1b(KOMP)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 BCM
IMPC		 2.06×10-06
Camsap3
Camsap3tm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 2.28×10-06
Gys2
Gys2tm1a(KOMP)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
EuroPhenome		 2.35×10-06
Myl12b
Myl12btm1a(EUCOMM)Wtsi 		HOM   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
MGP		 2.62×10-06
Mysm1
Mysm1tm1a(KOMP)Wtsi 		HOM   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
EuroPhenome		 2.94×10-06
Usp20
Usp20tm1a(EUCOMM)Hmgu 		HOM   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 3.87×10-06
Clvs1
Clvs1tm1.1(KOMP)Vlcg 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 3.98×10-06
Cdca8
Cdca8tm1a(KOMP)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
MGP		 4.73×10-06
Cisd1
Cisd1em1(IMPC)Hmgu 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 HMGU
IMPC		 4.80×10-06
Adgrb1
Adgrb1tm2a(EUCOMM)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 4.98×10-06
Izumo1r
Izumo1rtm2a(KOMP)Wtsi 		HOM   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 4.99×10-06
Cnbp
Cnbptm1b(KOMP)Wtsi 		HET   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 5.90×10-06
Tppp
Tppptm1.1(KOMP)Vlcg 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 6.19×10-06
Tenm4
Tenm4em1(IMPC)Tcp 		HOM Late adult increased circulating chloride level Chloride
Clinical Chemistry		 TCP
IMPC		 6.24×10-06
Arl4a
Arl4atm1Asch 		HOM Early adult increased circulating chloride level Chloride
Clinical chemistry (GMC)		 HMGU
EuroPhenome		 7.41×10-06
Carf
Carftm1.1(KOMP)Vlcg 		HOM   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 8.31×10-06
Traf2
Traf2tm1a(EUCOMM)Wtsi 		HET   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 9.58×10-06
Mdk
Mdktm1.1(KOMP)Mbp 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 1.04×10-05
Ing4
Ing4em1(IMPC)Tcp 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 TCP
IMPC		 1.32×10-05
Spmap2l
Spmap2ltm1b(KOMP)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 BCM
IMPC		 1.56×10-05
Entpd1
Entpd1tm1b(EUCOMM)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 HMGU
IMPC		 1.57×10-05
Baz1b
Baz1btm2a(KOMP)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
EuroPhenome		 1.58×10-05
Cldn34b2
Cldn34b2tm1a(KOMP)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 1.61×10-05
Sympk
Sympktm1a(EUCOMM)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
EuroPhenome		 1.65×10-05
Mcrs1
Mcrs1tm1.1(KOMP)Vlcg 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 1.66×10-05
Aff3
Aff3tm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 1.70×10-05
Fbxw18
Fbxw18em1(IMPC)Ccpcz 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 1.72×10-05
Fbxl3
Fbxl3em1(IMPC)Ccpcz 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 1.77×10-05
Plppr5
Plppr5em1(IMPC)Ccpcz 		HOM   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 1.90×10-05
Zfp341
Zfp341tm1a(KOMP)Wtsi 		HOM   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 2.13×10-05
Rnf7
Rnf7tm1a(EUCOMM)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 MRC Harwell
EuroPhenome		 2.25×10-05
Nes
Nestm1b(KOMP)Wtsi 		HOM   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 2.48×10-05
Cpgi5563
Cpgi5563tm1.1(NCC)WCS 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 2.51×10-05
Sesn3
Sesn3tm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
MGP		 2.52×10-05
Brms1
Brms1tm1.1(KOMP)Vlcg 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 2.54×10-05
Macir
Macirtm1.1(KOMP)Vlcg 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 2.67×10-05
Ufl1
Ufl1tm1a(EUCOMM)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
MGP		 2.70×10-05
Ppie
Ppieem1(IMPC)Tcp 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 TCP
IMPC		 2.77×10-05
Ajap1
Ajap1tm1b(EUCOMM)Hmgu 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 3.09×10-05
Eif4g1
Eif4g1em1(IMPC)Hmgu 		HET   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 HMGU
IMPC		 3.46×10-05
Ptpn20
Ptpn20tm1b(KOMP)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 3.65×10-05
Aqp6
Aqp6tm1b(EUCOMM)Hmgu 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 HMGU
IMPC		 4.09×10-05
Kmt5b
Kmt5btm1a(KOMP)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
MGP		 4.17×10-05
Tyro3
Tyro3em1(IMPC)Ccpcz 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 CCP-IMG
IMPC		 4.23×10-05
Mtif3
Mtif3tm1b(EUCOMM)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 HMGU
IMPC		 4.85×10-05
Zfp536
Zfp536tm1.1(KOMP)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 5.17×10-05
C1qa
C1qatm1b(EUCOMM)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 5.35×10-05
Atrip
Atriptm1b(KOMP)Wtsi 		HET Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 5.37×10-05
Chtf18
Chtf18tm1b(KOMP)Wtsi 		HET   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 6.90×10-05
Bhlhe40
Bhlhe40tm1b(KOMP)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 WTSI
IMPC		 7.00×10-05
Htr7
Htr7tm1b(KOMP)Wtsi 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 7.28×10-05
Ermp1
Ermp1tm1.1(KOMP)Vlcg 		HOM Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 7.34×10-05
Dnajc14
Dnajc14tm1.1(KOMP)Vlcg 		HOM   Early adult increased circulating chloride level Chloride
Clinical Chemistry		 JAX
IMPC		 8.59×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Clinical chemistry (GMC)
Fasted Bleed
Terminal Bleed
Urine Analysis

 Phenotype associations stats

2.08% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating chloride level (77/3706)

0.88% females (32/3654) 1.13% males (41/3627)

Select a parameter    



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