Phenotype: increased heart weight

Definition greater than average weight of the heart compared to controls

Related
Synonyms
  • increased left ventricle weight
  • increased left ventricle weight
  • increased heart right ventricle weight
  • increased heart right ventricle weight
  • increased heart right atrium weight
  • increased heart left atrium weight
Show more

MP browserMP:0002833

Phenotype associations stats

1.59% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased heart weight (64/4027)

1.09% females (43/3956) 1.35% males (54/3991)

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Gene variants with increased heart weight

Total number of significant genotype-phenotype associations: 97

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM Female postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 0.0
Mybpc3
Mybpc3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.17E-19
Slc25a4
Slc25a4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 1.89E-19
Gnas
Gnastm1Jop
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 2.14E-11
Sik1
Sik1tm1.1(KOMP)Vlcg
HOM Male postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 3.7E-11
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | MGP 6.73E-11
Ttc39a
Ttc39atm1b(KOMP)Mbp
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 1.91E-10
Ndufs3
Ndufs3tm1a(EUCOMM)Wtsi
HET Male postnatal increased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 2.15E-9
Rab19
Rab19tm1b(EUCOMM)Hmgu
HOM Male postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 4.53E-9
Lcn2
Lcn2tm1b(KOMP)Wtsi
HOM Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 3.43E-8
Rap1gap2
Rap1gap2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 3.62E-8
Cidec
Cidectm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 5.1E-8
Grm6
Grm6tm1b(EUCOMM)Wtsi
HOM Female postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 5.49E-8
Srcin1
Srcin1tm1.1(KOMP)Vlcg
HET Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 7.6E-8
Dynlrb2
Dynlrb2tm1a(KOMP)Wtsi
HET Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 8.06E-8
Exd1
Exd1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 9.62E-8
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.14E-7
Asns
Asnstm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | MGP 1.61E-7
Ash1l
Ash1ltm2b(EUCOMM)Hmgu
HET Male postnatal increased heart weight Heart Weight | Heart weight MARC | IMPC 1.65E-7
2810408A11Rik
2810408A11Riktm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | MGP 3.77E-7
Dcbld2
Dcbld2tm1a(KOMP)Wtsi
HOM Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 6.99E-7
Gpld1
Gpld1tm1.1(KOMP)Vlcg
HOM Male postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 7.41E-7
Mtmr12
Mtmr12tm1b(KOMP)Wtsi
HOM Female postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 7.54E-7
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 8.04E-7
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 9.2E-7
Smurf2
Smurf2tm1b(EUCOMM)Wtsi
HET Male postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.91E-6
Mpdz
Mpdzem1(IMPC)J
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 2.06E-6
Gpr101
Gpr101tm1b(KOMP)Mbp
HOM Female postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 2.67E-6
Lama4
Lama4tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 2.81E-6
Epb41l5
Epb41l5tm1a(EUCOMM)Hmgu
HET Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | MGP 3.14E-6
Rimklb
Rimklbtm1.1(KOMP)Vlcg
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 3.22E-6
Rnf10
Rnf10tm1b(KOMP)Wtsi
HET Male postnatal increased heart weight Heart Weight | Heart weight TCP | IMPC 4.07E-6
Lrrc15
Lrrc15tm1b(KOMP)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 5.26E-6
Rpa1
Rpa1tm1b(KOMP)Wtsi
HET Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 5.57E-6
Pabpc4
Pabpc4tm1a(KOMP)Wtsi
HOM Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 8.27E-6
Rab36
Rab36tm1b(KOMP)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 8.91E-6
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Male postnatal increased heart weight Heart Weight | Heart weight KMPC | IMPC 9.35E-6
Pacsin2
Pacsin2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 9.76E-6
Ptpn5
Ptpn5tm1b(KOMP)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 1.24E-5
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Male postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.28E-5
Stx8
Stx8tm2a(EUCOMM)Wtsi
HOM Female postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.35E-5
Tnfaip1
Tnfaip1tm1a(EUCOMM)Wtsi
HOM Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 2.46E-5
Fbxo43
Fbxo43em1(IMPC)Marc
HOM Male postnatal increased heart weight Heart Weight | Heart weight MARC | IMPC 2.54E-5
Tmem255b
Tmem255btm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | MGP 2.56E-5
Gsto2
Gsto2tm2a(KOMP)Wtsi
HOM Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 2.92E-5
Ttc28
Ttc28tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight TCP | IMPC 3.28E-5
Sparc
Sparctm1a(EUCOMM)Wtsi
HOM Female postnatal increased heart weight Heart weight/tibia length | Heart weight WTSI | MGP 3.3E-5
Timm50
Timm50tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 3.65E-5
Dppa1
Dppa1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 4.39E-5
Lrig1
Lrig1tm1a(EUCOMM)Wtsi
HOM Male postnatal increased heart weight Heart Dissection | Heart weight WTSI | MGP 4.42E-5
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 4.49E-5
Gabarapl2
Gabarapl2tm1b(EUCOMM)Hmgu
HET Male postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 4.55E-5
Bbox1
Bbox1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 5.13E-5
Zc3hc1
Zc3hc1tm1a(KOMP)Wtsi
HET Male postnatal increased heart weight Heart Dissection | Heart weight WTSI | MGP 5.44E-5
Ttll10
Ttll10em1(IMPC)J
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 5.5E-5
Gimap8
Gimap8tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 5.99E-5
Galnt12
Galnt12em1(IMPC)J
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 6.26E-5
Xylb
Xylbtm1a(EUCOMM)Hmgu
HOM Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 6.26E-5
Ino80
Ino80tm1a(EUCOMM)Hmgu
HET Female postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 6.4E-5
Ccdc57
Ccdc57tm1a(EUCOMM)Wtsi
HET Female postnatal increased heart weight Heart Dissection | Heart weight WTSI | MGP 7.82E-5
Hspb1
Hspb1tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 8.07E-5
Dcp2
Dcp2tm1b(KOMP)Wtsi
HET Female Male postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 8.29E-5
Nalcn
Nalcnem1(IMPC)Mbp
HET Female Male postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 8.35E-5
Phex
Phexnot yet available
HOM Female postnatal increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 9.56E-5

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