Phenotype: decreased brain size

Definition
smaller appearance of the brain
Synonyms
reduced brain size,  microencephaly,  micrencephaly,  smaller brain size,  small brain
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased brain size

Total number of significant genotype-phenotype associations: 65

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Arhgef2
Arhgef2em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Ccdc124
Ccdc124tm1b(KOMP)Wtsi
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
MARC
IMPC
0.00
Cd36
Cd36em1(IMPC)Mbp
HOM Late adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Chsy1
Chsy1em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Dagla
Daglatm1a(EUCOMM)Wtsi
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
MARC
IMPC
0.00
Dusp8
Dusp8em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Fmo5
Fmo5em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Gpc1
Gpc1em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Grik5
Grik5em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Hectd3
Hectd3tm1(NCOM)Cmhd
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
MARC
IMPC
0.00
Id3
Id3em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Kif6
Kif6em1(IMPC)Ccpcz
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Lhcgr
Lhcgrtm1(KOMP)Vlcg
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
MARC
IMPC
0.00
Mapk6
Mapk6em1(IMPC)Mbp
HET Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Msi2
Msi2em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Nav1
Nav1em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Pdcd6ip
Pdcd6ipem1(IMPC)Mbp
HOM Late adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Pdcd6ip
Pdcd6ipem1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Rtn4rl2
Rtn4rl2em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Sbf1
Sbf1em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Selenot
Selenotem1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Serping1
Serping1em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Sox4
Sox4em1(IMPC)Mbp
HET Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Taar3
Taar3em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Tle3
Tle3em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Tnfrsf11b
Tnfrsf11bem1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Ubqln4
Ubqln4em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Zbtb16
Zbtb16em1(IMPC)Mbp
HOM Early adult decreased brain size Brain
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Pdcd6ip
Pdcd6ipem1(IMPC)Mbp
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
5.58×10-42
Sbf1
Sbf1em1(IMPC)Mbp
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
5.54×10-35
Msi2
Msi2em1(IMPC)Mbp
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
3.78×10-33
Dusp8
Dusp8em1(IMPC)Mbp
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
8.73×10-18
Gh
Ghtm1.1(KOMP)Vlcg
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
2.86×10-11
Ssbp2
Ssbp2tm1b(KOMP)Wtsi
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
2.33×10-10
Gpc1
Gpc1em1(IMPC)Mbp
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
1.73×10-08
Negr1
Negr1tm1b(KOMP)Wtsi
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
2.83×10-08
Snph
Snphtm1.1(KOMP)Vlcg
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
6.61×10-08
Ubqln4
Ubqln4em1(IMPC)Mbp
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
8.84×10-08
Cpt1c
Cpt1ctm1b(EUCOMM)Wtsi
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
1.59×10-07
Gkn2
Gkn2tm1.1(KOMP)Vlcg
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
2.64×10-07
Peli1
Peli1tm1b(EUCOMM)Wtsi
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
2.72×10-07
Tmem106b
Tmem106btm2b(KOMP)Wtsi
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
4.99×10-07
Emx1
Emx1tm1.1(KOMP)Vlcg
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
9.53×10-07
Ccdc92
Ccdc92tm1b(KOMP)Mbp
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
2.04×10-06
Ckb
Ckbtm1.1(KOMP)Wtsi
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
2.95×10-06
Rspo1
Rspo1tm1.1(KOMP)Vlcg
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
4.27×10-06
Creb3
Creb3tm1.1(KOMP)Vlcg
HET Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
9.46×10-06
Fnbp1l
Fnbp1ltm1.1(KOMP)Vlcg
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
1.43×10-05
Tmem248
Tmem248tm1.1(KOMP)Vlcg
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
2.49×10-05
Rnf10
Rnf10em1(IMPC)Mbp
HOM Early adult decreased brain weight Brain weight
Organ Weight
UC Davis
IMPC
6.03×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Organ Weight

 Phenotype associations stats

6.67% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased brain size (43/645)

37.50% females (15/40) 5.89% males (38/645)



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