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Phenotype: abnormal femur morphology

Definition
any structural anomaly of the long bone of the thigh
Synonyms
femur dysplasia
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal femur morphology

Total number of significant genotype-phenotype associations: 21

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM Early adult abnormal femur morphology Femur
X-ray		 WTSI
IMPC		 3.82×10-17
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM Early adult abnormal femur morphology Femur
X-ray		 WTSI
IMPC		 3.82×10-17
Col9a2
Col9a2tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal femur morphology Femur
X-ray		 MRC Harwell
IMPC		 2.53×10-14
Lrrk1
Lrrk1tm1b(KOMP)Wtsi 		HOM Early adult abnormal femur morphology Femur
X-ray		 MRC Harwell
IMPC		 2.53×10-14
Cyp27b1
Cyp27b1tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal femur morphology Femur
X-ray		 TCP
IMPC		 9.26×10-13
Fbn2
Fbn2em1(IMPC)Rbrc 		HOM Early adult abnormal femur morphology Femur
X-ray		 RBRC
IMPC		 6.97×10-11
Tent5a
Tent5aem1(IMPC)Ccpcz 		HOM Early adult abnormal femur morphology Femur
X-ray		 CCP-IMG
IMPC		 7.95×10-10
Timp1
Timp1tm1b(EUCOMM)Hmgu 		HEM Early adult abnormal femur morphology Femur
X-ray		 MRC Harwell
IMPC		 2.53×10-09
Pitx1
Pitx1em1(IMPC)Wtsi 		HET Early adult abnormal femur morphology Femur
X-ray		 WTSI
IMPC		 6.01×10-09
Col1a2
Col1a2tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal femur morphology Femur
X-ray		 BCM
IMPC		 6.11×10-07
Ctrc
Ctrctm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal femur morphology Femur
X-ray		 HMGU
IMPC		 3.10×10-06
Chpf
Chpftm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal femur morphology Femur
X-ray		 HMGU
IMPC		 4.41×10-06
Bnip2
Bnip2tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal femur morphology Femur
X-ray		 WTSI
IMPC		 5.28×10-06
Slc38a2
Slc38a2tm1a(KOMP)Wtsi 		HET Early adult abnormal femur morphology Femur
X-ray		 WTSI
IMPC		 5.28×10-06

Download data as:   TSV   XLS

 The way we measure

Procedure
X-ray
Cortical Bone MicroCT
Femoral Microradiography
X-Ray
X-Ray (GMC)

 Phenotype associations stats

0.57% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal femur morphology (14/2463)

0.29% females (7/2450) 0.49% males (12/2455)

Select a parameter    



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