Gene: Syk

Order

Name spleen tyrosine kinase

Synonyms Sykb

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:99515    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Syk

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Syk data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Syktm1b(EUCOMM)Hmgu HOM Female Male n/a 0.0
abnormal bone structure Syktm1b(EUCOMM)Hmgu HET Female Male postnatal 2.88E-10
decreased grip strength Syktm1b(EUCOMM)Hmgu HET Female Male postnatal 1.35E-8
increased bone mineral content Syktm1b(EUCOMM)Hmgu HET Female Male postnatal 1.43E-7
increased total body fat amount Syktm1b(EUCOMM)Hmgu HET Female Male postnatal 3.14E-6
decreased lean body mass Syktm1b(EUCOMM)Hmgu HET Female Male postnatal 2.4E-5

Download data as: TSV XLS



Expression

Expression data not available

Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    9 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Syktm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Syktm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene