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Gene: Crb2 MGI:2679260

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Gene Summary

Name:
crumbs family member 2
Synonyms:
N/A

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal vibrissa morphology Crb2tm1a(KOMP)Wtsi HET Early adult 5.87×10-06
preweaning lethality, complete penetrance Crb2tm1a(KOMP)Wtsi HOM   Early adult 0.00
abnormal retina morphology Crb2tm1a(KOMP)Wtsi HET Early adult 1.06×10-06

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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DSS Histology

Images

8 Images

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X-ray

XRay Images Forepaw

14 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

15 Images

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X-ray

XRay Images Skull Lateral Orientation

13 Images

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Legacy Phenotype Associated Images
Crb2tm1a(KOMP)Wtsi
WT, Female, WTSI
Crb2tm1a(KOMP)Wtsi
WT, Female, WTSI
Crb2tm1a(KOMP)Wtsi
WT, Female, WTSI
Crb2tm1a(KOMP)Wtsi
WT, Female, WTSI
Crb2tm1a(KOMP)Wtsi
WT, Female, WTSI

View all 126 images

Crb2tm1a(KOMP)Wtsi
abnormal retinal pigmentation, abnormal retina morphology, right eye, HET, Male, WTSI
Crb2tm1a(KOMP)Wtsi
abnormal retinal pigmentation, right eye, abnormal retina morphology, HET, Male, WTSI
Crb2tm1a(KOMP)Wtsi
HET, Female, WTSI
Crb2tm1a(KOMP)Wtsi
abnormal retina morphology, right eye, abnormal retinal pigmentation, HET, Male, WTSI
Crb2tm1a(KOMP)Wtsi
abnormal retina morphology, left eye, abnormal retinal pigmentation, HET, Male, WTSI

View all 27 images

Human diseases caused by Crb2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Crb2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ventriculomegaly With Cystic Kidney Disease
Hydrocephalus, Ventricular septal defect OMIM:219730
Focal Segmental Glomerulosclerosis 9
OMIM:616220
Genetic Steroid-Resistant Nephrotic Syndrome
ORPHA:656

The table below shows human diseases predicted to be associated to Crb2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Retinal Dysplasia, Primary
Retinal dysplasia, Falciform retinal fold OMIM:312550
Stargardt Disease 1
Macular degeneration, Retinitis pigmentosa inversa, Bull's eye maculopathy OMIM:248200
Retinal Dystrophy, Reticular Pigmentary, Of Posterior Pole
Drusen, Reticular pigmentary degeneration, Retinal dystrophy OMIM:267800
Macular Degeneration, Age-Related, 13
Drusen, Macular degeneration, Choroidal neovascularization, Macular scar OMIM:615439
Retinitis Pigmentosa 36
Optic disc pallor, Bone spicule pigmentation of the retina, Macular degeneration, Rod-cone dystro... OMIM:610599
Exudative Vitreoretinopathy 7
Retinal detachment, Exudative vitreoretinopathy, Retinal hole, Retinal fold, Retinal degeneration OMIM:617572
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Macular Degeneration, Age-Related, 6
Macular degeneration OMIM:613757
Macular Degeneration, Age-Related, 7
Macular degeneration OMIM:610149
Macular Degeneration, Age-Related, 4
Macular degeneration OMIM:610698
Macular Degeneration, Age-Related, 15
Macular degeneration OMIM:615591
Macular Degeneration, Age-Related, 2
Macular degeneration OMIM:153800
Macular Degeneration, Age-Related, 11
Macular degeneration OMIM:611953
Exudative Vitreoretinopathy 3
Retinal detachment, Retinal exudate, Exudative vitreoretinopathy, Retinal hole, Retinal fold OMIM:605750
Retinoschisis 1, X-Linked, Juvenile
Retinal detachment, Retinal atrophy, Retinal pigment epithelial atrophy, Mizuo phenomenon, Macula... OMIM:312700
Retinal Degeneration And Epilepsy
Retinal degeneration OMIM:267740
Late-Onset Retinal Degeneration
Sub-RPE deposits, Choroidal neovascularization, Chorioretinal degeneration, Retinopathy, Retinal ... OMIM:605670
X-Linked Retinal Dysplasia
Abnormal retinal vascular morphology, Abnormality of retinal pigmentation, Retinal dysplasia ORPHA:1852
Sorsby Pseudoinflammatory Fundus Dystrophy
Retinal atrophy, Choroidal neovascularization, Retinal pigment epithelial atrophy, Macular dystro... ORPHA:59181
Retinopathy, Pericentral Pigmentary, Dominant
Bone spicule pigmentation of the retina, Retinal atrophy, Retinal dystrophy, Pigmentary retinopat... OMIM:180210
Familial Drusen
Abnormality of retinal pigmentation, Macular drusen, Peripapillary chorioretinal atrophy, Choroid... ORPHA:75376
Macular Degeneration, Age-Related, 1
Macular drusen, Choroidal neovascularization, Geographic atrophy, Macular hemorrhage, Macular deg... OMIM:603075
Birdshot Chorioretinopathy
Retinal detachment, Optic disc pallor, Abnormal chorioretinal morphology, Choroidal neovasculariz... ORPHA:179
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Reese Retinal Dysplasia
Remnants of the hyaloid vascular system, Retinal dysplasia OMIM:266400
Retinitis Pigmentosa 70
Optic disc pallor, Macular degeneration, Rod-cone dystrophy, Retinal degeneration, Attenuation of... OMIM:615922
Retinitis Pigmentosa 50
Retinal detachment, Optic disc pallor, Retinal flecks, Rod-cone dystrophy, Attenuation of retinal... OMIM:613194
Retinitis Pigmentosa 32
Optic disc pallor, Bone spicule pigmentation of the retina, Pigmentary retinopathy, Photoreceptor... OMIM:609913
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Retinitis Pigmentosa 13
Bone spicule pigmentation of the retina, Optic disc drusen, Perifoveal ring of hyperautofluoresce... OMIM:600059
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Ventricular septal defect, Spina bifida, Anencephaly, Cleft palate, Ectopic anus, Hypoplastic lef... ORPHA:2476
Frontal Encephalocele
Encephalocele, Hydrocephalus, Spina bifida ORPHA:1931
Acalvaria
Cleft palate, Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
Senior-Loken Syndrome 7
Retinal degeneration OMIM:613615
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida, Mitral valve prolapse OMIM:211960
Thoraco-Abdominal Enteric Duplication
Dextrocardia, Intestinal malrotation, Meningocele, Duodenal stenosis, Abnormal tricuspid valve mo... ORPHA:1759
Coloboma Of Optic Nerve
Retinal detachment, Optic disc coloboma OMIM:120430
Vitreoretinal Degeneration, Snowflake Type
Retinal detachment, Snowflake vitreoretinal degeneration, Optically empty vitreous, Retinal dots OMIM:193230
Exudative Vitreoretinopathy 2, X-Linked
Retinal detachment, Peripheral retinal avascularization, Subretinal exudate, Intraretinal exudate... OMIM:305390
Fryns Microphthalmia Syndrome
Neural tube defect, Bilateral cleft lip and palate OMIM:600776
Exudative Vitreoretinopathy 1
Retinal detachment, Peripheral retinal avascularization, Vitreous floaters, Exudative vitreoretin... OMIM:133780
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Isolated Klippel-Feil Syndrome
Ventricular septal defect, Spina bifida, Cleft palate, Ectopic anus, Anal atresia ORPHA:2345
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Schisis Association
Encephalocele, Spina bifida, Anencephaly, Tracheoesophageal fistula, Cleft palate, Anal atresia ORPHA:63862
Isolated Hemihyperplasia
Myelomeningocele ORPHA:2128
Myopia 2, Autosomal Dominant
Retinal detachment OMIM:160700
Myopia 3, Autosomal Dominant
Retinal detachment OMIM:603221
Myopia 5, Autosomal Dominant
Retinal detachment OMIM:608474
Myopia 25, Autosomal Dominant
Retinal detachment OMIM:617238
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Ventricular septal defect, Situs inversus totalis, Hydrocephalus, Meningocele, Ane... ORPHA:1908
Congenital Vertical Talus
Myelomeningocele ORPHA:178382
Subependymal Nodular Heterotopia
Occipital encephalocele, Myelomeningocele, Meningocele, Nasofrontal encephalocele ORPHA:101030
Meckel Syndrome, Type 4
Encephalocele, Ventricular septal defect, Hydrocephalus, Meningocele, Anencephaly, Cleft palate, ... OMIM:611134
Caudal Duplication
Myelomeningocele, Intestinal duplication, Spina bifida ORPHA:1756
Acropectorovertebral Dysplasia
High, narrow palate, Cleft palate, Spina bifida ORPHA:957
Vitreoretinopathy, Neovascular Inflammatory
Peripheral retinal neovascularization, Retinal detachment, Large hyperpigmented retinal spots, Po... OMIM:193235
Neural Tube Defects, Susceptibility To
Spina bifida occulta, Hydrocephalus, Myelomeningocele, Anencephaly OMIM:182940
Wildervanck Syndrome
Meningocele ORPHA:3456
Diaphanospondylodysostosis
Myelomeningocele, Cleft palate ORPHA:66637
Meckel Syndrome, Type 2
Encephalocele, Intestinal malrotation, Meningocele, Anencephaly, Cleft palate, Intrauterine growt... OMIM:603194
Humero-Radial Synostosis
Meningocele ORPHA:3265
Blepharocheilodontic Syndrome 1
Neural tube defect, Anal atresia OMIM:119580
Muscle-Eye-Brain Disease
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:588
Sirenomelia
Anal atresia, Tracheoesophageal fistula, Spina bifida, Sirenomelia ORPHA:3169
Chiari Malformation Type Ii
Cervical myelopathy, Myelomeningocele, Hydrocephalus, Spina bifida OMIM:207950
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Bicuspid aortic valve, Spina bifida, Patent ductus arteriosus, Anomalous pulmonary venous return,... ORPHA:1120
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism, Anal atresia ORPHA:63260
Anophthalmia Plus Syndrome
Cleft palate, Spina bifida, Bilateral cleft lip and palate ORPHA:1104
Triploidy
Intestinal malrotation, Hydrocephalus, Meningocele, Cleft palate, Macroglossia, Abnormal cardiac ... ORPHA:3376
Alg3-Cdg
Macroglossia, Neural tube defect, Cardiomyopathy, High palate, Abnormal uvula morphology ORPHA:79321
Camptodactyly Syndrome, Guadalajara Type 1
Intrauterine growth retardation, High palate, Spina bifida ORPHA:1327
Czeizel-Losonci Syndrome
Dextrocardia, Spina bifida, Myelomeningocele, Hydrocephalus, Tracheoesophageal fistula, High pala... ORPHA:2437
Autosomal Recessive Spondylocostal Dysostosis
Meningocele, Cleft palate, Anomalous pulmonary venous return, Umbilical hernia, Spina bifida occu... ORPHA:2311
Enlarged Parietal Foramina
Occipital encephalocele, Myelomeningocele, Cleft palate ORPHA:60015
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele, Bilateral cleft lip and palate ORPHA:2003
Waardenburg Syndrome Type 1
Cleft palate, Meningocele, Aganglionic megacolon, Spina bifida ORPHA:894
Joubert Syndrome 14
Encephalocele, Ventricular septal defect, Hydrocephalus, Meningocele, Cleft palate OMIM:614424
Cerebrocostomandibular Syndrome
Ventricular septal defect, Spina bifida, Myelomeningocele, Meningocele, Cleft palate, Glossoptosi... ORPHA:1393
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Glossoptosis, Meningocele ORPHA:2031
Neurocutaneous Melanocytosis
Meningocele ORPHA:2481
Amish Lethal Microcephaly
Cleft soft palate, Spina bifida ORPHA:99742
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Neural tube defect, Occipital meningocele ORPHA:268810
Lateral Meningocele Syndrome
Ventricular septal defect, High, narrow palate, Meningocele, High palate, Umbilical hernia ORPHA:2789
Lateral Meningocele Syndrome
Bicuspid aortic valve, Ventricular septal defect, Patent ductus arteriosus, Hydrocephalus, Mening... OMIM:130720
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Neu-Laxova Syndrome 2
Intrauterine growth retardation, High palate, Cleft palate, Spina bifida OMIM:616038
Spondylocostal Dysostosis 4, Autosomal Recessive
Anal stenosis, Dextrocardia, Situs inversus totalis, Myelomeningocele, Hydrocephalus, Ectopic anu... OMIM:613686
Mosaic Trisomy 9
Ventricular septal defect, Intestinal malrotation, Spina bifida, Dextrocardia, Abnormal heart val... ORPHA:99776
Pelvis-Shoulder Dysplasia
Spina bifida, Hydrocephalus, Cleft palate, Hydranencephaly, Microglossia ORPHA:2839
Acromelic Frontonasal Dysplasia
Encephalocele, Meningocele, Median cleft palate ORPHA:1827
Limb Body Wall Complex
Encephalocele, Ventricular septal defect, Spina bifida, Myelomeningocele, Hydrocephalus, Anenceph... ORPHA:2369
Sacral Defect With Anterior Meningocele
Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract, Rectal abscess OMIM:600145
Iniencephaly
Encephalocele, Spina bifida, Hydrocephalus, Myelomeningocele, Anencephaly, Spinal dysraphism, Hol... ORPHA:63259
Lumbar Syndrome
Anal atresia, Myelomeningocele, Ectopic anus, Spina bifida ORPHA:83628
Chromosome 17P13.1 Deletion Syndrome
Spina bifida, High, narrow palate, Hydrocephalus, High palate, Umbilical hernia OMIM:613776
Vacterl With Hydrocephalus
Spina bifida, Aqueductal stenosis, Esophageal atresia, Hydrocephalus, Tracheoesophageal fistula, ... ORPHA:3412
Trisomy 18
Ventricular septal defect, Spina bifida, Esophageal atresia, Anencephaly, Cleft palate, Narrow pa... ORPHA:3380
Curry-Jones Syndrome
Anal stenosis, Intestinal pseudo-obstruction, Intestinal malrotation, Lipomyelomeningocele, Occip... OMIM:601707
Heterotaxy, Visceral, 1, X-Linked
Cardiomegaly, Aqueductal stenosis, Dextrotransposition of the great arteries, Atrial septal defec... OMIM:306955
Trisomy 20P
Umbilical hernia, Ectopic anus, Spina bifida ORPHA:261318
Cloacal Exstrophy
Intestinal malrotation, Spina bifida, Myelomeningocele, Intestinal duplication, Anal atresia ORPHA:93929
Focal Dermal Hypoplasia
Ventricular septal defect, Spina bifida, Patent ductus arteriosus, Abnormal cardiac septum morpho... ORPHA:2092
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Hamartoma of tongue, Hydrocephalus, Anencephaly, Cleft palate, Atrial septal defect, Occipital me... OMIM:616546
Lathosterolosis
Intrauterine growth retardation, Meningocele, High palate ORPHA:46059
Phakomatosis Pigmentokeratotica
Spina bifida ORPHA:2874
Basal Cell Nevus Syndrome 1
Spina bifida, Hydrocephalus, Hamartomatous stomach polyps, Cardiac fibroma, Cleft palate, Cardiac... OMIM:109400
Phocomelia, Schinzel Type
High, narrow palate, Meningocele, Tracheoesophageal fistula, Cleft palate, Intrauterine growth re... ORPHA:2879
Pagod Syndrome
Encephalocele, Spina bifida, Situs inversus totalis, Meningocele, Hypoplastic left heart ORPHA:991
Nail-Patella Syndrome
Cleft palate, Spina bifida OMIM:161200
Fibular Hemimelia
Spina bifida, Abnormal heart morphology ORPHA:93323
Neu-Laxova Syndrome
Spina bifida, Submucous cleft hard palate, Cleft palate, Intrauterine growth retardation, Bifid u... ORPHA:2671
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Orofaciodigital Syndrome Vi
Hamartoma of tongue, Cleft palate, Lobulated tongue, High palate, Hypoplastic left heart, Occipit... OMIM:277170
Vater/Vacterl Association
Occipital encephalocele, Ventricular septal defect, Spina bifida, Esophageal atresia, Patent duct... OMIM:192350
Neu-Laxova Syndrome 1
Ventricular septal defect, Spina bifida, Patent ductus arteriosus, Cleft palate, Stillbirth, Shor... OMIM:256520
Fanconi Anemia
Aganglionic megacolon, Spina bifida, Aplasia/Hypoplasia of the uvula, Patent ductus arteriosus, H... ORPHA:84
Jacobsen Syndrome
Ventricular septal defect, Intestinal malrotation, Spina bifida, Pyloric stenosis, Abnormality of... ORPHA:2308
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Occipital encephalocele, Meningocele ORPHA:397715
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Patent ductus arteriosus, Atrioventricular canal defect, Bifid uvula, Spina bifida OMIM:619480
22Q11.2 Deletion Syndrome
Aganglionic megacolon, Intestinal malrotation, Spina bifida, Ventricular septal defect, Abnormal ... ORPHA:567
Hallermann-Streiff Syndrome
High, narrow palate, Narrow palate, High palate, Spina bifida OMIM:234100
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Bicuspid aortic valve, Ventricular septal defect, Spina bifida, Tetralogy of Fallot, Perimembrano... ORPHA:508498
Thrombocytopenia-Absent Radius Syndrome
Ventricular septal defect, Spina bifida, Patent ductus arteriosus, Tetralogy of Fallot, Cleft pal... OMIM:274000
Holoprosencephaly 7
Bilateral cleft palate, Median cleft lip and palate, Alobar holoprosencephaly, Hydrocephalus, Cle... OMIM:610828
Neurofibromatosis, Type I
Aqueductal stenosis, Hydrocephalus, Spina bifida OMIM:162200
Knobloch Syndrome 1
Occipital encephalocele, Pyloric stenosis, Patent ductus arteriosus, Occipital meningocele, Spina... OMIM:267750
Aicardi Syndrome
Cleft palate, Spina bifida, Hiatus hernia OMIM:304050
Campomelic Dysplasia
Spina bifida, Hydrocephalus, Submucous cleft hard palate, Cleft palate, Spinal dysraphism, Abnorm... OMIM:114290
Marfan Syndrome
Mitral valve calcification, High, narrow palate, Meningocele, Cleft palate, Mitral valve prolapse ORPHA:558
Koolen-De Vries Syndrome Due To A Point Mutation
Bicuspid aortic valve, Ventricular septal defect, Spina bifida, Hydrocephalus, Abnormal heart mor... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Bicuspid aortic valve, Ventricular septal defect, Spina bifida, Hydrocephalus, Abnormal heart mor... ORPHA:363958
Arima Syndrome
Occipital meningocele, Esophageal varix OMIM:243910
Rubinstein-Taybi Syndrome 1
Ventricular septal defect, Spina bifida, High, narrow palate, Patent ductus arteriosus, Cleft pal... OMIM:180849
Split Cord Malformation
Cervical spina bifida, Myelomeningocele, Lipomyelomeningocele, Meningocele, Hydrocephalus ORPHA:573278
Semilobar Holoprosencephaly
Hydrocephalus, Cleft palate, Abnormal heart morphology, Neural tube defect, High palate, Bifid uvula ORPHA:220386
Alobar Holoprosencephaly
Hydrocephalus, Cleft palate, Abnormal heart morphology, Neural tube defect, High palate, Bifid uvula ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Hydrocephalus, Cleft palate, Abnormal heart morphology, Neural tube defect, High palate, Bifid uvula ORPHA:93926
Lobar Holoprosencephaly
Hydrocephalus, Cleft palate, Abnormal heart morphology, Neural tube defect, High palate, Bifid uvula ORPHA:93924
Exstrophy-Epispadias Complex
Anal stenosis, Spina bifida, Hydrocephalus, Abnormal heart morphology, Anal atresia ORPHA:322
Otopalatodigital Syndrome, Type Ii
Spina bifida, Hydrocephalus, Cleft palate, Stillbirth, Atrial septal defect, Umbilical hernia OMIM:304120
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Occipital meningocele, High palate, Narrow palate OMIM:276820
Ventriculomegaly With Cystic Kidney Disease
Hydrocephalus, Ventricular septal defect OMIM:219730
Focal Segmental Glomerulosclerosis 9
OMIM:616220
Genetic Steroid-Resistant Nephrotic Syndrome
ORPHA:656

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Crb2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Crb2.

There are 6 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Crb2tm1a(KOMP)Wtsi PMC7263671
Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells (April 2020) Crb2tm1c(KOMP)Wtsi 32290105
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Crb2tm1a(KOMP)Wtsi PMC6671969
Targeted deletion of Crb1/Crb2 in the optic vesicle models key features of leber congenital amaurosis 8. Developmental biology (May 2019) Crb2tm1c(KOMP)Wtsi Crb2tm1a(KOMP)Wtsi 31145883
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Crb2tm1a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Crb2tm1a(KOMP)Wtsi PMC5827107

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MGI Allele Allele Type Produced
Crb2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Crb2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Crb2tm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Crb2tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice
Crb2tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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