Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal seminal vesicle morphology | Krt26em1(IMPC)Kmpc | HOM | Early adult | 0.00 | ||
abnormal skin coloration | Krt26em1(IMPC)Kmpc | HOM | Late adult | 4.36×10-05 | ||
abnormal digit morphology | Krt26em1(IMPC)Kmpc | HOM | Late adult | 2.46×10-05 | ||
decreased heart weight | Krt26em1(IMPC)Kmpc | HOM | Late adult | 2.71×10-05 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Krt26 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Hyperpigmentation With Or Without Hypopigmentation, Familial Progressive | Progressive hyperpigmentation, Hypermelanotic macule, Hypopigmented skin patches, Multiple lentig... | OMIM:145250 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Krt26tm38477(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Krt26tm38477(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Krt26tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Krt26tm354748(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Krt26em1(IMPC)Kmpc | Deletion | Mice |
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