Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
preweaning lethality, incomplete penetrance | Kmt5btm1a(KOMP)Wtsi | HOM | Early adult | 0.00 | ||
decreased body weight | Kmt5btm1a(KOMP)Wtsi | HET | Early adult | 1.84×10-07 | ||
decreased body weight | Kmt5btm1a(KOMP)Wtsi | HOM | Early adult | 1.24×10-11 | ||
decreased bone mineral content | Kmt5btm1a(KOMP)Wtsi | HET | Early adult | 9.20×10-05 | ||
decreased body length | Kmt5btm1a(KOMP)Wtsi | HET | Early adult | 1.86×10-06 | ||
decreased total body fat amount | Kmt5btm1a(KOMP)Wtsi | HET | Early adult | 6.03×10-05 | ||
abnormal tail movements | Kmt5btm1a(KOMP)Wtsi | HET | Early adult | 7.74×10-06 | ||
increased thermal nociceptive threshold | Kmt5btm1a(KOMP)Wtsi | HET | Early adult | 3.90×10-05 | ||
increased circulating chloride level | Kmt5btm1a(KOMP)Wtsi | HOM | Early adult | 4.17×10-05 | ||
decreased body length | Kmt5btm1a(KOMP)Wtsi | HOM | Early adult | 2.18×10-06 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | N/A | heterozygote | 100% (2 of 2) |
Aorta | N/A | heterozygote | Not available |
Blood vessel | N/A | heterozygote | 50% (1 of 2) |
Bone | N/A | heterozygote | Ambiguous |
Brain | N/A | heterozygote | 100% (2 of 2) |
Brainstem | N/A | heterozygote | Not available |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cartilage tissue | N/A | heterozygote | 100% (2 of 2) |
Cerebellum | N/A | heterozygote | Not available |
Cerebral cortex | N/A | heterozygote | Not available |
Eye | N/A | heterozygote | 100% (2 of 2) |
Gall bladder | N/A | heterozygote | 50% (1 of 2) |
Heart | N/A | heterozygote | 100% (2 of 2) |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Kidney | N/A | heterozygote | 100% (2 of 2) |
Large intestine | N/A | heterozygote | 100% (2 of 2) |
Liver | N/A | heterozygote | 50% (1 of 2) |
Lower urinary tract | N/A | heterozygote | 100% (2 of 2) |
Lung | N/A | heterozygote | 100% (2 of 2) |
Lymph node | N/A | heterozygote | 100% (2 of 2) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
Esophagus | N/A | heterozygote | 100% (2 of 2) |
Olfactory lobe | N/A | heterozygote | Not available |
Ovary | N/A | heterozygote | 50% (1 of 2) |
Oviduct | N/A | heterozygote | 50% (1 of 2) |
Pancreas | N/A | heterozygote | 50% (1 of 2) |
Parathyroid gland | N/A | heterozygote | 50% (1 of 2) |
Peripheral nervous system | N/A | heterozygote | 100% (2 of 2) |
Peyer's patch | N/A | heterozygote | 100% (2 of 2) |
Pituitary gland | N/A | heterozygote | 50% (1 of 2) |
Prostate gland | N/A | heterozygote | 50% (1 of 2) |
Skeletal muscle tissue | N/A | heterozygote | 100% (2 of 2) |
Skin | N/A | heterozygote | 100% (2 of 2) |
Small intestine | N/A | heterozygote | 100% (2 of 2) |
Spinal cord | N/A | heterozygote | 100% (2 of 2) |
Spleen | N/A | heterozygote | 100% (2 of 2) |
Stomach | N/A | heterozygote | 100% (2 of 2) |
Striatum | N/A | heterozygote | Not available |
Testis | N/A | heterozygote | 50% (1 of 2) |
Thymus | N/A | heterozygote | 100% (2 of 2) |
Thyroid gland | N/A | heterozygote | 100% (2 of 2) |
Trachea | N/A | heterozygote | 100% (2 of 2) |
Uterus | N/A | heterozygote | 50% (1 of 2) |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood vessel | |
bone | 0.0% |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
heart | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
oesophagus | |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
peripheral nervous system | 0.0% |
peyer's patch | |
pituitary gland | 0.0% |
prostate gland | 0.0% |
skeletal muscle tissue | |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
striatum | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
trachea | 0.0% |
uterus | 0.0% |
white adipose tissue | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Kmt5b by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Intellectual Developmental Disorder, Autosomal Dominant 51 | Failure to thrive | OMIM:617788 |
The table below shows human diseases predicted to be associated to Kmt5b by phenotypic similarity.
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
Phenotype | Allele | Zygosity | Sex | Life Stage |
---|---|---|---|---|
Kidney - process of degenerative change | Kmt5btm1a(KOMP)Wtsi | HET | Early adult | |
Liver - lipid deposition | Kmt5btm1a(KOMP)Wtsi | HOM | Early adult | |
Liver - lipid deposition | Kmt5btm1a(KOMP)Wtsi | HET | Early adult |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kmt5b.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. | Nucleic acids research (December 2017) | Kmt5btm1a(KOMP)Wtsi | PMC5716182 |
Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation. | Cell stem cell (December 2015) | Kmt5btm1a(KOMP)Wtsi | 26669898 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Kmt5btm39901(L1L2_st2) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Kmt5btm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Kmt5btm39901(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Kmt5btm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Kmt5btm2e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
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