Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Wholemount images | heterozygote | 50% (2 of 4) |
Bone | Wholemount images | heterozygote | 0.0% (0 of 4) |
Brain | Wholemount images | heterozygote | 100% (4 of 4) |
Brainstem | Wholemount images | heterozygote | 100% (4 of 4) |
Cartilage tissue | Wholemount images | heterozygote | 0.0% (0 of 4) |
Cerebellum | Wholemount images | heterozygote | 100% (4 of 4) |
Cerebral cortex | Wholemount images | heterozygote | 100% (4 of 4) |
Hippocampus | Wholemount images | heterozygote | 100% (4 of 4) |
Hypothalamus | Wholemount images | heterozygote | 100% (4 of 4) |
Olfactory lobe | Wholemount images | heterozygote | 100% (4 of 4) |
Parathyroid gland | Wholemount images | heterozygote | 100% (4 of 4) |
Peripheral nervous system | Wholemount images | heterozygote | 50% (2 of 4) |
Prostate gland | Wholemount images | heterozygote | 25% (1 of 4) |
Spinal cord | Wholemount images | heterozygote | 100% (4 of 4) |
Striatum | Wholemount images | heterozygote | 100% (4 of 4) |
Testis | Wholemount images | heterozygote | 25% (1 of 4) |
Trachea | Wholemount images | heterozygote | 50% (2 of 4) |
Trigeminal V nerve | Wholemount images | heterozygote | 50% (2 of 4) |
Vas deferens | Wholemount images | heterozygote | 25% (1 of 4) |
Aorta | N/A | heterozygote | 0.0% (0 of 4) |
Blood | N/A | heterozygote | Not available |
Bone marrow | N/A | heterozygote | Not available |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
Cecum | N/A | heterozygote | 0.0% (0 of 3) |
Chest bone | N/A | heterozygote | 0.0% (0 of 2) |
Colon | N/A | heterozygote | 0.0% (0 of 2) |
Cranium | N/A | heterozygote | 0.0% (0 of 2) |
Diaphragm | N/A | heterozygote | 0.0% (0 of 2) |
Duodenum | N/A | heterozygote | 0.0% (0 of 2) |
Epididymis | N/A | heterozygote | Not available |
Esophagus | N/A | heterozygote | 0.0% (0 of 4) |
Eye | N/A | heterozygote | 0.0% (0 of 4) |
Gall bladder | N/A | heterozygote | 25% (1 of 4) |
Gonadal fat pad | N/A | heterozygote | Not available |
Harderian gland | N/A | heterozygote | 0.0% (0 of 2) |
Heart | N/A | heterozygote | 0.0% (0 of 4) |
Hindlimb | N/A | heterozygote | 0.0% (0 of 2) |
Ileum | N/A | heterozygote | 0.0% (0 of 2) |
Jejunum | N/A | heterozygote | 0.0% (0 of 2) |
Kidney | N/A | heterozygote | 50% (2 of 4) |
Large intestine | N/A | heterozygote | 0.0% (0 of 4) |
Liver | N/A | heterozygote | 0.0% (0 of 4) |
Lower urinary tract | N/A | heterozygote | 0.0% (0 of 4) |
Lung | N/A | heterozygote | 0.0% (0 of 4) |
Lymph node | N/A | heterozygote | 0.0% (0 of 4) |
Main olfactory bulb | N/A | heterozygote | Not available |
Mammary gland | N/A | heterozygote | 0.0% (0 of 4) |
Mesenteric adipose tissue | N/A | heterozygote | Not available |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 4) |
Midbrain | N/A | heterozygote | Not available |
Oral epithelium | N/A | heterozygote | 0.0% (0 of 4) |
Ovary | N/A | heterozygote | 0.0% (0 of 4) |
Oviduct | N/A | heterozygote | 0.0% (0 of 4) |
Pancreas | N/A | heterozygote | 0.0% (0 of 4) |
Parotid gland | N/A | heterozygote | Not available |
Penis | N/A | heterozygote | 0.0% (0 of 2) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 4) |
Pituitary gland | N/A | heterozygote | 50% (2 of 4) |
Quadriceps | N/A | heterozygote | 0.0% (0 of 2) |
Sciatic nerve | N/A | heterozygote | Not available |
Skeletal muscle | N/A | heterozygote | 0.0% (0 of 4) |
Skin | N/A | heterozygote | 0.0% (0 of 4) |
Small intestine | N/A | heterozygote | 0.0% (0 of 4) |
Spleen | N/A | heterozygote | 0.0% (0 of 4) |
Stomach pyloric region | N/A | heterozygote | Not available |
Stomach | N/A | heterozygote | 0.0% (0 of 4) |
Sublingual gland | N/A | heterozygote | Not available |
Submandibular gland | N/A | heterozygote | 0.0% (0 of 2) |
Thalamus | N/A | heterozygote | Not available |
Thymus | N/A | heterozygote | 0.0% (0 of 4) |
Thyroid gland | N/A | heterozygote | 25% (1 of 4) |
Tongue | N/A | heterozygote | 0.0% (0 of 2) |
Urinary bladder | N/A | heterozygote | 0.0% (0 of 4) |
Uterus | N/A | heterozygote | 0.0% (0 of 4) |
Vagina | N/A | heterozygote | 0.0% (0 of 2) |
Vascular system | N/A | heterozygote | 0.0% (0 of 4) |
Vesicular gland | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Brain | N/A | heterozygote | Ambiguous |
Ear | N/A | heterozygote | Ambiguous |
Embryo | N/A | heterozygote | 100% (2 of 2) |
Outer ear | N/A | heterozygote | Ambiguous |
Eye | N/A | heterozygote | 100% (2 of 2) |
Footplate | N/A | heterozygote | 100% (2 of 2) |
Forearm | N/A | heterozygote | 100% (2 of 2) |
Forebrain | N/A | heterozygote | Ambiguous |
Forelimb | N/A | heterozygote | 100% (2 of 2) |
Handplate | N/A | heterozygote | 100% (2 of 2) |
Head | N/A | heterozygote | 100% (2 of 2) |
Hindbrain | N/A | heterozygote | Ambiguous |
Hindlimb | N/A | heterozygote | 100% (2 of 2) |
Lower leg | N/A | heterozygote | 100% (2 of 2) |
Mandibular process | N/A | heterozygote | Ambiguous |
Maxillary process | N/A | heterozygote | Ambiguous |
Midbrain | N/A | heterozygote | Ambiguous |
Nose | N/A | heterozygote | 100% (2 of 2) |
Chorioallantoic placenta | N/A | heterozygote | Not available |
Skeleton | N/A | heterozygote | Ambiguous |
Skin | N/A | heterozygote | 100% (2 of 2) |
Tail somite | N/A | heterozygote | Ambiguous |
Tail | N/A | heterozygote | 100% (2 of 2) |
Upper arm | N/A | heterozygote | 100% (2 of 2) |
Upper leg | N/A | heterozygote | 100% (2 of 2) |
Vibrissa | N/A | heterozygote | Ambiguous |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood | |
bone | 0.0% |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
chest bone | |
colon | |
cranium | |
diaphragm | 0.0% |
duodenum | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | |
heart | 0.0% |
hindlimb | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
ileum | 0.0% |
jejunum | |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
main olfactory bulb | 0.0% |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | |
midbrain | 0.0% |
olfactory lobe | 0.0% |
oral epithelium | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
stomach pyloric region | 0.0% |
striatum | 0.0% |
sublingual gland | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thalamus | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vagina | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
brain | 0.0% |
ear | 0.0% |
embryo | 0.0% |
external ear | Ambiguous |
eye | 0.0% |
footplate | 0.0% |
forearm | Ambiguous |
forebrain | 0.0% |
forelimb | 0.0% |
handplate | 0.0% |
head | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
lower leg | Ambiguous |
mandibular process | 0.0% |
maxillary process | 0.0% |
midbrain | 0.0% |
nose | Ambiguous |
placenta | Ambiguous |
skeleton | Ambiguous |
skin | 0.0% |
tail | 0.0% |
tail somite group | 0.0% |
upper arm | Ambiguous |
upper leg | Ambiguous |
vibrissa | Ambiguous |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Rnft2 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Cephalin Lipidosis | Abnormality of the spleen | OMIM:212800 | |
Tuftsin Deficiency | Abnormality of the spleen | OMIM:191150 | |
Ceroid storage disease | Abnormality of the spleen | OMIM:214200 | |
Splenomegaly Syndrome With Splenic Germinal Center Hypoplasia And Reduced Circulating T Helper Cells | Hypersplenism, Splenomegaly, Pancytopenia, Decreased helper T cell proportion | OMIM:183350 | |
Asplenia, Isolated Congenital | Asplenia, Thrombocytosis, Howell-Jolly bodies | OMIM:271400 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Rnft2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Rnft2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | Mice |
Rnft2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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