Gene: Ube3c

Name ubiquitin protein ligase E3C

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2140998   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Ube3c

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Ube3c data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased lean body mass Ube3ctm1b(EUCOMM)Hmgu HOM Female Male postnatal 4.26E-10
decreased respiratory quotient Ube3ctm1b(EUCOMM)Hmgu HOM Female Male postnatal 3.57E-7
decreased body length Ube3ctm1b(EUCOMM)Hmgu HOM Female Male postnatal 4.71E-7
decreased bone mineral density Ube3ctm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.64E-6
abnormal gait Ube3ctm1b(EUCOMM)Hmgu HOM Female postnatal 1.66E-6
decreased heart weight Ube3ctm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.22E-5
increased circulating alkaline phosphatase level Ube3ctm1b(EUCOMM)Hmgu HOM Female postnatal 1.33E-5
decreased food intake Ube3ctm1b(EUCOMM)Hmgu HOM Female Male postnatal 3.63E-5
decreased fluid intake Ube3ctm1b(EUCOMM)Hmgu HOM Female postnatal 7.32E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 Yes (5/393) (6/6)
Aorta 4 Yes (1/562) (6/6)
Bone 4 Yes (1/539)
Brain 4 Yes (6/562) (6/6)
Brainstem 4 No (4/562) (6/6)
Brown adipose tissue 4 Yes (6/6)
Cartilage tissue 4 No (1/562) (6/6)
Cecum 4 Yes (1/355) (6/6)
Cerebellum 4 No (4/562) (6/6)
Cerebral cortex 4 No (5/562) (6/6)
Chest bone 4 Yes (6/6)
Colon 4 No (1/99) (6/6)
Cranium 4 No
Diaphragm 4 Yes
Duodenum 4 Yes (1/99) (6/6)
Epididymis 4 Yes (4/106)
Esophagus 4 Yes (2/393) (6/6)
Eye 4 Yes (1/562) (6/6)
Gall bladder 4 Yes
Gonadal fat pad 4 No
Harderian gland 4 Yes (6/6)
Heart 4 Yes (3/562) (6/6)
Hindlimb 4 No
Hippocampus 4 No (5/562) (6/6)
Hypothalamus 4 No (4/562) (6/6)
Ileum 4 Yes (1/99) (6/6)
Jejunum 4 Yes (1/99) (6/6)
Kidney 4 Yes (20/562) (6/6)
Large intestine 4 Yes (12/562) (6/6)
Liver 4 Yes (6/6)
Lower urinary tract 4 No (3/562) (6/6)
Lung 4 Yes (3/562) (6/6)
Lymph node 4 Yes (1/562)
Main olfactory bulb 4 Yes (6/6)
Mammary gland 4 Yes (3/6)
Mesenteric lymph node 4 Yes
Mesenteric adipose tissue 4 Yes
Midbrain 4 No (6/6)
Olfactory lobe 4 No (4/393) (6/6)
Oral epithelium 4 Yes (5/6)
Ovary 4 Yes (1/562)
Oviduct 4 Yes (2/562) (3/6)
Pancreas 4 Yes (6/562) (6/6)
Parathyroid gland 4 Yes (2/540) (5/6)
Parotid gland 4 Yes (6/6)
Penis 4 Yes (3/6)
Peripheral nervous system 4 No (3/562) (6/6)
Peyer's patch 4 No (1/393)
Pituitary gland 4 Yes (1/562) (5/6)
Prostate gland 4 Yes (5/562)
Quadriceps 4 Yes
Sciatic nerve 4 Yes (6/6)
Skeletal muscle 4 No
Skin 4 Yes (1/562) (6/6)
Small intestine 4 No (11/562) (6/6)
Spinal cord 4 Yes (3/562) (6/6)
Spleen 4 Yes (4/562)
Stomach 4 Yes (9/562)
Stomach pyloric region 4 No
Striatum 4 No (4/562) (6/6)
Sublingual gland 4 Yes (6/6)
Submandibular gland 4 Yes (1/104)
Testis 4 Yes (4/562) (3/6)
Thalamus 4 No (6/6)
Thymus 4 Yes
Thyroid gland 4 Yes (16/562)
Tongue 4 Yes (6/6)
Trachea 4 Yes (3/562) (6/6)
Trigeminal V nerve 4 Yes (6/6)
Urinary bladder 4 Yes (6/6)
Uterus 4 Yes (2/562) (3/6)
Vagina 4 Yes (3/6)
Vas deferens 4 No (1/360)
Vascular system 4 No (1/393) (6/6)
Vesicular gland 4 Yes (3/6)
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    limb
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    adipose tissue
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 7 (6/440) (7/7)
Ear 7 (1/440)
Embryo 7 (1/440) (7/7)
Eye 7 (1/440) (7/7)
Foot 7
Forearm 7
Forebrain 7 (1/440)
Forelimb 7 (1/440)
Hand 7
Head 7 (5/440) (7/7)
Heart 7 (1/440) (7/7)
Hindbrain 7 (5/440) (7/7)
Hindlimb 7 (1/440)
Liver 7 (1/440)
Lower leg 7
Lung 7 (1/440)
Mandibular process 7 (1/440)
Maxillary process 7 (1/440)
Midbrain 7 (1/440)
Oral cavity 7 (1/440)
Skin 7 (1/440)
Tail 7 (1/440) (7/7)
Tail somite 7 (1/440)
Upper arm 7
Upper leg 7
  • head(8)
    Eye expression
    EMAPA:16198 eye
  • limb(8)
    Forelimb ambiguous
    EMAPA:17412 forelimb


Associated Images

Associated Images
  • Embryo LacZ: LacZ images wholemount
    105 Images
  • Adult LacZ: LacZ Images Wholemount
    436 Images
  • Eye Morphology: Images Ophthalmoscopy
    4 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Eye Morphology: Images Slit Lamp
    1 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Ube3ctm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Ube3ctm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene