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Gene: Rala MGI:1927243

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Gene Summary

Name:
v-ral simian leukemia viral oncogene A (ras related)
Synonyms:
Ral,  3010001O15Rik,  Rasl1

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Ralatm1a(EUCOMM)Wtsi HOM   Early adult 0.00

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

14 Images

View images
Legacy Phenotype Associated Images
Ralatm1a(EUCOMM)Wtsi
HET, Male, WTSI
Ralatm1a(EUCOMM)Wtsi
HET, Male, WTSI
Ralatm1a(EUCOMM)Wtsi
HET, Male, WTSI
Ralatm1a(EUCOMM)Wtsi
HET, Female, WTSI
Ralatm1a(EUCOMM)Wtsi
HET, Female, WTSI

View all 74 images

Ralatm1a(EUCOMM)Wtsi
cornea/lens fusion, HET, Male, WTSI
Ralatm1a(EUCOMM)Wtsi
right eye, HET, Female, WTSI
Ralatm1a(EUCOMM)Wtsi
persistence of hyaloid vascular system, HET, Female, WTSI

Human diseases caused by Rala mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Rala by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hiatt-Neu-Cooper Neurodevelopmental Syndrome
OMIM:619311

The table below shows human diseases predicted to be associated to Rala by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Joubert Syndrome 15
Exencephaly OMIM:614464
Neural Tube Defects, Susceptibility To
Spina bifida occulta, Hydrocephalus, Myelomeningocele, Anencephaly OMIM:182940
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Encephalocele, Exencephaly ORPHA:2211
Sacral Defect With Anterior Meningocele
Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract OMIM:600145
Hiatt-Neu-Cooper Neurodevelopmental Syndrome
OMIM:619311

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rala

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rala.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Ralatm1a(EUCOMM)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Ralatm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Ralatm1a(EUCOMM)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Ralatm1a(EUCOMM)Wtsi PMC5827107

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ralatm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ralatm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Ralatm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ralatm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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