Gene: Bbs5

Order

Name Bardet-Biedl syndrome 5 (human)

Synonyms
  • 2700023J09Rik
  • 1700049I01Rik

Status ES CellsMice
tm1a
Mice
tm1b
Mice
tm1c
phenotype data available

Links MGI:1919819    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Bbs5

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Bbs5 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased bone mineral content Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased lean body mass Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased total body fat amount Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 0.0
short tibia Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.55E-38
increased fasted circulating glucose level Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 2.16E-14
decreased grip strength Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 2.86E-10
increased mean corpuscular volume Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 4.67E-10
abnormal retina morphology Bbs5tm1b(EUCOMM)Wtsi HOM Male postnatal 1.34E-9
increased hemoglobin content Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.63E-9
abnormal gait Bbs5tm1b(EUCOMM)Wtsi HOM Male postnatal 4.48E-9
decreased bone mineral density Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.14E-8
abnormal heart left ventricle morphology Bbs5tm1b(EUCOMM)Wtsi HOM Female postnatal 2.25E-8
decreased respiratory quotient Bbs5tm1b(EUCOMM)Wtsi HOM Male postnatal 2.39E-8
decreased spleen weight Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 2.74E-8
thrombocytopenia Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 4.27E-7
increased circulating glucose level Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 7.59E-7
increased leukocyte cell number Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 7.98E-7
impaired glucose tolerance Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.07E-6
increased circulating aspartate transaminase level Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 2.04E-6
increased hematocrit Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 2.76E-6
increased lymphocyte cell number Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 9.78E-6
increased circulating alkaline phosphatase level Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.02E-5
decreased heart rate variability Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.43E-5
increased circulating alanine transaminase level Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.72E-5
abnormal behavior Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 4.26E-5
decreased heart weight Bbs5tm1b(EUCOMM)Wtsi HOM Female Male postnatal 4.94E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (5/393) (1/4)
Aorta 4 No (1/562)
Bone 4 No (1/539)
Brain 4 No (6/562) (4/4)
Brainstem 4 No (4/562)
Brown adipose tissue 4 No
Cartilage tissue 4 No (1/562) (1/4)
Cerebellum 4 No (4/562)
Cerebral cortex 4 No (5/562)
Esophagus 4 No (2/393)
Eye 4 No (1/562)
Gall bladder 4 No
Heart 4 No (3/562)
Hippocampus 4 No (5/562)
Hypothalamus 4 No (4/562) (1/4)
Kidney 4 No (20/562)
Large intestine 4 No (12/562)
Liver 4 No
Lower urinary tract 4 No (3/562)
Lung 4 No (3/562)
Lymph node 4 No (1/562)
Mammary gland 4 No
Olfactory lobe 4 No (4/393)
Oral epithelium 4 No
Ovary 4 No (1/562)
Oviduct 4 No (2/562)
Pancreas 4 No (6/562)
Parathyroid gland 4 No (2/540)
Peripheral nervous system 4 No (3/562)
Peyer's patch 4 No (1/393)
Pituitary gland 4 No (1/562)
Prostate gland 4 No (5/562) (1/4)
Skeletal muscle 4 No
Skin 4 No (1/562)
Small intestine 4 No (11/562)
Spinal cord 4 No (3/562) (4/4)
Spleen 4 No (4/562)
Stomach 4 No (9/562) (1/4)
Striatum 4 No (4/562)
Testis 4 No (4/562) (2/4)
Thymus 4 No
Thyroid gland 4 No (16/562)
Trachea 4 No (3/562) (1/4)
Uterus 4 No (2/562)
Vascular system 4 No (1/393) (1/4)
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    endocrine system respiratory system digestive system cardiovascular system
    nervous system
    set of connective tissues
    reproductive system
    exocrine system
    trunk
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1 (6/440) (2/2)
Ear 1 (1/440)
Embryo 1 (1/440) (2/2)
Eye 1 (1/440)
Foot 1
Forebrain 1 (1/440)
Forelimb 1 (1/440)
Hand 1
Head 1 (5/440) (2/2)
Heart 1 (1/440)
Hindbrain 1 (5/440) (2/2)
Hindlimb 1 (1/440)
Liver 1 (1/440)
Lung 1 (1/440)
Mandibular process 1 (1/440)
Maxillary process 1 (1/440)
Midbrain 1 (1/440)
Oral cavity 1 (1/440)
Skin 1 (1/440)
Tail 1 (1/440)
Tail somite 1 (1/440)


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    12 Images
  • Echo: M-Mode Images
    28 Images
  • X-ray: XRay Images Dorso Ventral
    16 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    8 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • X-ray: XRay Images Skull Lateral Orientation
    2 Images
  • Adult LacZ: LacZ Images Wholemount
    4 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Bbs5tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Bbs5tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Bbs5tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Bbs5tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Bbs5tm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp)
Vector
Gene