Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased circulating cholesterol level | Atad3atm1a(KOMP)Wtsi | HET | Early adult | 5.11×10-07 | ||
decreased circulating HDL cholesterol level | Atad3atm1a(KOMP)Wtsi | HET | Early adult | 6.13×10-06 | ||
preweaning lethality, complete penetrance | Atad3atm1a(KOMP)Wtsi | HOM | Early adult | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Atad3a by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Pontocerebellar Hypoplasia, Hypotonia, And Respiratory Insufficiency Syndrome, Neonatal Lethal | Hypocholesterolemia | OMIM:618810 | |
Ocular Anomalies-Axonal Neuropathy-Developmental Delay Syndrome | Delayed puberty | ORPHA:496790 | |
Harel-Yoon Syndrome | OMIM:617183 |
The table below shows human diseases predicted to be associated to Atad3a by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Atad3a.
There are 6 publications which use IMPC produced mice or data.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Atad3atm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Atad3atm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
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