Gene: Lss

Order

Name lanosterol synthase

Synonyms
  • 2810025N20Rik
  • D10Ertd116e
  • Osc

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1336155    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Lss

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Lss data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to organogenesis Lsstm1b(KOMP)Wtsi HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Lsstm1b(KOMP)Wtsi HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Lsstm1b(KOMP)Wtsi HOM Female Male n/a 0.0
abnormal retinal vasculature morphology Lsstm1b(KOMP)Wtsi HET Male postnatal 1.05E-8
abnormal retinal blood vessel morphology Lsstm1b(KOMP)Wtsi HET Male postnatal 2.99E-8
abnormal lens morphology Lsstm1b(KOMP)Wtsi HET Female Male postnatal 6.35E-8
increased leukocyte cell number Lsstm1b(KOMP)Wtsi HET Female Male postnatal 1.47E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393)
Aorta 2 No (1/562)
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cecum 2 No (1/355)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Olfactory lobe 2 No (4/393)
Oral epithelium 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Trigeminal V nerve 2 No
Uterus 2 No (2/562)
Vas deferens 2 No (1/360)
Vascular system 2 No (1/393)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    nervous system
    reproductive system
    integumental system
    trunk
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2 (1/45)
Axial skeleton 2 (1/47)
Brain 2 (6/482)
Central nervous system ganglion 2 (1/47)
Cranium 2 (1/44)
Dorsal root ganglion 2 (1/45)
Ear 2 (1/482)
Embryo 2 (1/482)
Outer ear 2 (1/45)
Eye 2 (1/482)
Femur pre-cartilage condensation 2 (1/44)
Foot 2 (1/482)
Forearm 2 (1/280)
Forebrain 2 (1/482)
Forelimb 2 (1/482)
Fronto-nasal process 2 (1/46)
Gut 2 (1/46)
Hand 2 (1/482)
Head 2 (5/482)
Head mesenchyme 2 (1/45)
Heart 2 (1/482)
Heart ventricle 2 (1/45)
Hindbrain 2 (6/482)
Hindlimb 2 (1/482)
Humerus pre-cartilage condensation 2 (1/44)
Inner ear 2 (1/44)
Intestine 2 (1/45)
Liver 2 (1/482)
Lower leg 2 (1/280)
Lung 2 (1/482)
Mandibular process 2 (1/482)
Maxillary process 2 (1/482)
Mesonephros of female 2 (1/44)
Mesonephros of male 2 (1/44)
Metanephros 2 (1/44)
Midbrain 2 (1/482)
Nasal septum 2 (1/45)
Nose 2 (1/47)
Notochord 2 (1/45)
Oral cavity 2 (1/482)
Outflow tract 2 (1/45)
Pancreas 2 (1/44)
Pericardium 2 (1/44)
Pharynx 2 (1/44)
Radius-ulna pre-cartilage condensation 2 (1/44)
Rib pre-cartilage condensation 2 (1/44)
Skeleton 2 (1/47)
Skin 2 (1/482)
Spinal cord 2 (1/46)
Stomach 2 (1/44)
Tail 2 (1/482)
Tail somite 2 (1/482)
Thoracic vertebral cartilage condensation 2 (1/44)
Tongue 2 (1/44)
Trachea 2 (1/46)
Trunk mesenchyme 2 (1/45)
Umbilical artery embryonic part 2 (1/45)
Umbilical vein embryonic part 2 (1/45)
Upper arm 2 (1/280)
Upper leg 2 (1/280)
Urinary system 2 (1/46)
Vibrissa 2 (1/45)


Associated Images

Associated Images
  • Adult LacZ: LacZ Images Wholemount
    5 Images
  • Embryo LacZ: LacZ images wholemount
    4 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Lsstm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Lsstm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene