Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
preweaning lethality, complete penetrance | Fntatm1b(KOMP)Wtsi | HOM | Early adult | 0.00 | ||
embryonic lethality prior to organogenesis | Fntatm1b(KOMP)Wtsi | HOM | E9.5 | 0.00 | ||
embryonic lethality prior to tooth bud stage | Fntatm1b(KOMP)Wtsi | HOM | E12.5 | 0.00 | ||
abnormal coat/hair pigmentation | Fntatm1b(KOMP)Wtsi | HET | Early adult | 4.75×10-06 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Aorta | Wholemount images | heterozygote | 16.67% (1 of 6) |
Brain | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Brainstem | Section images | heterozygote | 33.33% (2 of 6) |
Brown adipose tissue | Section images | heterozygote | 33.33% (2 of 6) |
Cecum | Section images | heterozygote | 75% (3 of 4) |
Cerebellum | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Chest bone | Wholemount images | heterozygote | 25% (1 of 4) |
Colon | Section images | heterozygote | 75% (3 of 4) |
Duodenum | Section images | heterozygote | 50% (2 of 4) |
Epididymis | Section images | heterozygote | 50% (2 of 4) |
Esophagus | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Eye | Wholemount images Section images | heterozygote | 33.33% (2 of 6) |
Harderian gland | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Heart | Section images | heterozygote | 33.33% (2 of 6) |
Ileum | Section images | heterozygote | 100% (4 of 4) |
Jejunum | Section images | heterozygote | 50% (2 of 4) |
Kidney | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Liver | Section images | heterozygote | 33.33% (2 of 6) |
Lung | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Mammary gland | Section images | heterozygote | 16.67% (1 of 6) |
Mesenteric adipose tissue | Wholemount images | heterozygote | 25% (1 of 4) |
Midbrain | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Olfactory lobe | Wholemount images Section images | heterozygote | 33.33% (2 of 6) |
Ovary | Wholemount images | heterozygote | 33.33% (2 of 6) |
Oviduct | Wholemount images | heterozygote | 33.33% (2 of 6) |
Pancreas | Wholemount images Section images | heterozygote | 50% (3 of 6) |
Parathyroid gland | Section images | heterozygote | 40% (2 of 5) |
Parotid gland | Section images | heterozygote | 25% (1 of 4) |
Penis | Section images | heterozygote | 25% (1 of 4) |
Pituitary gland | Wholemount images Section images | heterozygote | 33.33% (2 of 6) |
Prostate gland | Section images | heterozygote | 33.33% (2 of 6) |
Sciatic nerve | Wholemount images | heterozygote | 25% (1 of 4) |
Skin | Section images | heterozygote | 50% (3 of 6) |
Spinal cord | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Spleen | Section images | heterozygote | 33.33% (2 of 6) |
Stomach | Section images | heterozygote | 83.33% (5 of 6) |
Testis | Section images | heterozygote | 16.67% (1 of 6) |
Thymus | Section images | heterozygote | 50% (3 of 6) |
Thyroid gland | Wholemount images Section images | heterozygote | 50% (3 of 6) |
Tongue | Wholemount images Section images | heterozygote | 25% (1 of 4) |
Trachea | Section images | heterozygote | 16.67% (1 of 6) |
Trigeminal V nerve | Section images | heterozygote | 25% (1 of 4) |
Urinary bladder | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Uterus | Wholemount images | heterozygote | 33.33% (2 of 6) |
Vagina | Wholemount images | heterozygote | 25% (1 of 4) |
Vas deferens | Section images | heterozygote | 50% (2 of 4) |
Vesicular gland | Section images | heterozygote | 25% (1 of 4) |
Blood | N/A | heterozygote | 0.0% (0 of 4) |
Bone marrow | N/A | heterozygote | 0.0% (0 of 4) |
Bone | N/A | heterozygote | 100% (2 of 2) |
Cartilage tissue | N/A | heterozygote | 0.0% (0 of 6) |
Cerebral cortex | N/A | heterozygote | 0.0% (0 of 6) |
Diaphragm | N/A | heterozygote | 0.0% (0 of 4) |
Gall bladder | N/A | heterozygote | Not available |
Gonadal fat pad | N/A | heterozygote | 0.0% (0 of 4) |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | 0.0% (0 of 6) |
Hypothalamus | N/A | heterozygote | 0.0% (0 of 6) |
Large intestine | N/A | heterozygote | 83.33% (5 of 6) |
Lower urinary tract | N/A | heterozygote | 0.0% (0 of 6) |
Lymph node | N/A | heterozygote | 0.0% (0 of 6) |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 4) |
Peripheral nervous system | N/A | heterozygote | 0.0% (0 of 6) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 6) |
Quadriceps | N/A | heterozygote | 0.0% (0 of 4) |
Skeletal muscle | N/A | heterozygote | 0.0% (0 of 6) |
Small intestine | N/A | heterozygote | 66.67% (4 of 6) |
Stomach pyloric region | N/A | heterozygote | Not available |
Striatum | N/A | heterozygote | 0.0% (0 of 6) |
Sublingual gland | N/A | heterozygote | 0.0% (0 of 4) |
Submandibular gland | N/A | heterozygote | 0.0% (0 of 4) |
Vascular system | N/A | heterozygote | 33.33% (2 of 6) |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 6) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Axial skeleton | N/A | heterozygote | 100% (2 of 2) |
Brain | N/A | heterozygote | 28.57% (2 of 7) |
Central nervous system ganglion | N/A | heterozygote | 100% (2 of 2) |
Ear | N/A | heterozygote | 28.57% (2 of 7) |
Embryo | N/A | heterozygote | 28.57% (2 of 7) |
Eye | N/A | heterozygote | 28.57% (2 of 7) |
Footplate | N/A | heterozygote | 28.57% (2 of 7) |
Forebrain | N/A | heterozygote | 28.57% (2 of 7) |
Forelimb | N/A | heterozygote | 28.57% (2 of 7) |
Gut | N/A | heterozygote | 100% (2 of 2) |
Handplate | N/A | heterozygote | 28.57% (2 of 7) |
Head | N/A | heterozygote | 28.57% (2 of 7) |
Heart | N/A | heterozygote | 28.57% (2 of 7) |
Hindbrain | N/A | heterozygote | 28.57% (2 of 7) |
Hindlimb | N/A | heterozygote | 28.57% (2 of 7) |
Liver | N/A | heterozygote | 28.57% (2 of 7) |
Lung | N/A | heterozygote | 28.57% (2 of 7) |
Mandibular process | N/A | heterozygote | 28.57% (2 of 7) |
Maxillary process | N/A | heterozygote | 28.57% (2 of 7) |
Midbrain | N/A | heterozygote | 28.57% (2 of 7) |
Nose | N/A | heterozygote | 100% (2 of 2) |
Oral cavity | N/A | heterozygote | 28.57% (2 of 7) |
Chorioallantoic placenta | N/A | heterozygote | 100% (2 of 2) |
Skeleton | N/A | heterozygote | 100% (2 of 2) |
Skin | N/A | heterozygote | 28.57% (2 of 7) |
Spinal cord | N/A | heterozygote | 100% (2 of 2) |
Tail somite | N/A | heterozygote | 28.57% (2 of 7) |
Tail | N/A | heterozygote | 28.57% (2 of 7) |
Trachea | N/A | heterozygote | 100% (2 of 2) |
Urinary system | N/A | heterozygote | 100% (2 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood | |
bone | 0.0% |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
chest bone | |
colon | |
diaphragm | 0.0% |
duodenum | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | |
heart | 0.0% |
hindlimb | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
ileum | 0.0% |
jejunum | |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
stomach pyloric region | 0.0% |
striatum | 0.0% |
sublingual gland | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vagina | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
axial skeleton | Ambiguous |
brain | 0.0% |
central nervous system ganglion | Ambiguous |
ear | 0.0% |
embryo | 0.0% |
eye | 0.0% |
footplate | 0.0% |
forebrain | 0.0% |
forelimb | 0.0% |
gut | Ambiguous |
handplate | 0.0% |
head | 0.0% |
heart | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
liver | 0.0% |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
midbrain | 0.0% |
nose | Ambiguous |
oral cavity | 0.0% |
placenta | Ambiguous |
skeleton | Ambiguous |
skin | 0.0% |
spinal cord | Ambiguous |
tail | 0.0% |
tail somite group | 0.0% |
trachea | Ambiguous |
urinary system | Ambiguous |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Fnta by phenotypic similarity.
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MGI Allele | Allele Type | Produced |
---|---|---|
Fntatm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice, Tissue |
Fntatm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Fntatm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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