Gene: Mtf1

Order

Name metal response element binding transcription factor 1

Synonyms
  • metal response element-binding transcription factor 1
  • Thyls
  • metalloregulatory transcription factor
  • MTF-1

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:101786    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Mtf1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Mtf1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal craniofacial morphology Mtf1tm1b(KOMP)Wtsi HOM Female Male embryonic day 12.5 0.0
abnormal embryo size Mtf1tm1b(KOMP)Wtsi HOM Female Male embryonic day 12.5 0.0
abnormal forebrain morphology Mtf1tm1b(KOMP)Wtsi HOM Female Male embryonic day 12.5 0.0
anophthalmia Mtf1tm1b(KOMP)Wtsi HOM Male embryonic day 12.5 0.0
embryonic growth retardation Mtf1tm1b(KOMP)Wtsi HOM Female Male embryonic day 12.5 0.0
hemorrhage Mtf1tm1b(KOMP)Wtsi HET Female Male embryonic day 15.5 0.0
microphthalmia Mtf1tm1b(KOMP)Wtsi HOM Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Mtf1tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
decreased circulating glucose level Mtf1tm1b(KOMP)Wtsi HET Female Male postnatal 4.36E-10

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Epididymis 2 No (4/106) (1/2)
Esophagus 2 No (2/393) (2/2)
Eye 2 No (1/562) (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562)
Mammary gland 2 No
Midbrain 2 No (2/2)
Olfactory lobe 2 No (4/393) (2/2)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No (2/2)
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (2/2)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Submandibular gland 2 No (1/104)
Testis 2 No (4/562) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562) (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393) (2/2)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system integumental system urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482) (2/3)
Dorsal root ganglion 2 (1/45) Image Only
Ear 2 (1/482) Image Only
Embryo 2 (1/482) (2/3)
Eye 2 (1/482) (2/3)
Foot 2 (1/482) (2/3)
Forebrain 2 (1/482) (2/3)
Forelimb 2 (1/482) (2/3)
Fronto-nasal process 2 (1/46) Image Only
Hand 2 (1/482) (2/3)
Head 2 (5/482) (2/3)
Heart 2 (1/482) (2/3)
Hindbrain 2 (6/482) (2/3)
Hindlimb 2 (1/482) (2/3)
Liver 2 (1/482) (2/3)
Lung 2 (1/482) Image Only
Mandibular process 2 (1/482) (2/3)
Maxillary process 2 (1/482) (2/3)
Midbrain 2 (1/482) (2/3)
Nose 2 (1/47) (2/3)
Oral cavity 2 (1/482) Image Only
Skin 2 (1/482) Image Only
Spinal cord 2 (1/46) (2/3)
Tail 2 (1/482) (2/3)
Tail somite 2 (1/482) Image Only


Associated Images

Phenotype associated images not available

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Mtf1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Mtf1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Mtf1tm36746(L1L2_Bact_P)
Vector
Gene